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Figure 2: Current content of UPdb. UPdb consists of a list of 3874 m/z peaks found in human urine in the mass range of 803 to 199000 according to the MS platforms used. The database framework contains data for fractionation methods (separation technique or chip-type, capillary electrophoresis elution time), mass analyzer used (general technique and specific MS instrumentation used), peak specific data (average m/z and intensity and frequency above threshold), study-centric information ( , number of specimens tested, literature reference linking to PubMed, investigated disease, and species), experimental conditions (input volumes, wash conditions for solid phase extraction methods, and matrix used), protein links (identified protein name, accession number and link to external databases and internal PADB cross-references), and sample specific data (whether the sample was in vitro digested or not, from which tissue it originated, and whether it was further fractionated into subcellular components). Peaks that were classified as biomarkers are indicated in the disease biomarker column, together with a confidence score ( value), the regulation (up/down), and fold change in disease as well as substratified frequency %-values in control and disease samples.