Flow diagram indicating mevalonate pathway. PP (pyrophosphate), FDPS (Farnesyl pyrophosphate synthase), FDFT1 (farnesyl-diphosphate farnesyltransferase 1), FPP (Farnesylpyrophosphate), GGPP (geranylgeranyl pyrophosphate), Rho, Ras, Rab, Rac (small GTPases), and RASGRF2 (Ras-specific guanine nucleotide-releasing factor). ** and * show up and down regulation of genes and proteins respectively as observed in current study.