Research Article
SILAC-Based Quantitative Proteomic Analysis of Diffuse Large B-Cell Lymphoma Patients
Table 2
Annotation clusters according to DAVID using an EASE score of 0.01.
| | Name | Number of proteins | value |
| Annotation cluster 1 | Enrichment score 3.07 | | |
| | Actin binding | 8 | 0.00012 | | Cell projection | 7 | 0.00032 | | ARP2/3 protein complex | 3 | 0.00072 | | Cytoskeletal protein binding | 9 | 0.0072 |
| Annotation cluster 2 | Enrichment score 2.96 | | |
| | Mitochondrial inner membrane | 4 | 0.000079 | | Hydrogen ion transmembrane transporter activity | 6 | 0.00015 | | Inorganic cation transmembrane transporter activity | 7 | 0.0002 | | Respiratory chain | 5 | 0.00029 | | Monovalent inorganic cation transmembrane transporter activity | 6 | 0.00029 | | Membrane-associated complex | 4 | 0.00039 | | Cytochrome-c oxidase activity | 4 | 0.00051 | | Oxidoreductase activity, acting on heme group of donors, oxygen as acceptor | 4 | 0.00051 | | Heme-copper terminal oxidase activity | 4 | 0.00051 | | Oxidative phosphorylation | 4 | 0.00051 | | Transmembrane protein | 11 | 0.00058 | | Electron transfer | 4 | 0.0015 | | Generation of precursor metabolites and energy | 8 | 0.0019 | | Huntington’s disease | 7 | 0.0029 | | Oxidoreductase | 9 | 0.0036 | | Mitochondrion | 11 | 0.0039 |
| Annotation cluster 3 | Enrichment score 2.81 | | |
| | Antigen-processing and presentation of peptide antigen | 4 | 0.0005 | | MHC class I | 3 | 0.00087 | | Heterodimer | 5 | 0.0012 | | Antigen processing and presentation of peptide antigen via MHC class I | 3 | 0.004 |
| Annotation cluster 4 | Enrichment score 2.78 | | |
| | Vesicle coat | 5 | 0.000073 | | Retrograde vesicle-mediated transport, Golgi to ER | 4 | 0.00021 | | Cytoplasmic membrane-bounded vesicle | 12 | 0.00038 | | Membrane-bounded vesicle | 12 | 0.0005 | | Membrane coat | 5 | 0.00053 | | Golgi vesicle budding | 3 | 0.0014 | | Cytoplasmic vesicle | 12 | 0.0014 | | Melanosome | 5 | 0.0019 | | Pigment granule | 5 | 0.0019 | | Membrane budding | 3 | 0.0036 | | Golgi membrane | 6 | 0.005 | | Golgi apparatus | 13 | 0.0051 | | Membrane organization | 8 | 0.0055 |
| Annotation cluster 5 | Enrichment score 2.45 | | |
| | Nucleolus | 12 | 0.0027 | | Intracellular organelle lumen | 21 | 0.003 | | Organelle lumen | 21 | 0.004 | | Membrane-enclosed lumen | 21 | 0.005 |
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