Amphiphilic Poly(3-hydroxy alkanoate)s: Potential Candidates for Medical Applications

Table 2

Methods for the synthesis of the amphiphilic PHAs.

PHA	Synthesis	Product	Reference
PHB	Transesterification with mPEG2000 (in melt)	PHB-b-PEG	[25]
PHB	Transesterification with PEG2000 (in solution)	PHB-g-PEG	[29]
PHB	Transesterification with Diethylene glycol (in melt)	PHB-diol	[26]
PHO	UV-irradiation with methacrylated-PEG	PHO-g-PEG	[53]
PHU	UV-irradiation with methacrylated-PEG	PHO-g-PEG	[54]
PHO	Free radical polymerization with acrylate	PHO-g-Poly-glycerol diacrylate	[55]
PHA-un-	Free radical polymerization with saturated polyazoester based on PEG	PHA-g-PEG	[50]
PHOU	Epoxidation and reaction with diethanol amine	PHA with pendant amine side groups	[42]
PHOU	Epoxidation and reaction with hexamethylene diamine	Cross-linked PHOU	[41]
PHB	Condensation with chitosan	PHB-g-chitosan	[45]
PHO	Condensation with chitosan	PHO-chitosan	[46]
PHOU	Hydroxylation of the double bonds	PHOU with pendant-OH	[34, 37, 38]
PHOU	Carboxylation of the double bonds	PHOU with pendant-COOH	[35, 36]
PHB	Urethane formation of PHB and PCL containing dihydroxyl ends	PHB-g-PCL	[27, 28]
PHOU	Thiol addition of thio-maltose to double bonds	PHOU-g-sugar	[48]
PHOU	Esterification of carboxylated PHOU with PEG	PHOU-g- PEG	[56]