Table 1: Acid-base properties of the same PAA polymers.

PAA name and structurepKaI.P.Percentage of charged unitsIC50
B16F10 cell
pH = 5.5pH = 7.4(mg/mL)

161749.tab.001pKa1   = 2.1
pKa2   = 3.25
pKa3   = 7.5
5.52% (+)40% (−)>5

161749.tab.002pKa1   = 8.1
pKa2   = 6.9
pKa3   = 3.8
pKa4   = 2.8
>1095% (+)55% (+)3