About this Journal Submit a Manuscript Table of Contents
International Journal of Polymer Science
Volume 2011 (2011), Article ID 814163, 9 pages
http://dx.doi.org/10.1155/2011/814163
Review Article

Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China

Received 24 February 2011; Revised 5 April 2011; Accepted 12 April 2011

Academic Editor: Shanfeng Wang

Copyright © 2011 Xiaohong Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.