814163.fig.004
Figure 4: Imprinting process. (a) Solution mixture of template, functional monomer(s) (triangles and circles), crosslinking monomer, solvent, and initiator (I). (b) The prepolymerization complex is formed via covalent or noncovalent chemistry. (c) The formation of the network. (d) Wash step where original template is removed. (e) Rebinding of template. (f) In less crosslinked systems, movement of the macromolecular chains will produce areas of differing affinity and specificity (filled molecule is isomer of template) [31].