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International Journal of Polymer Science
Volume 2012 (2012), Article ID 564348, 11 pages
http://dx.doi.org/10.1155/2012/564348
Research Article

Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles

1Biomedical Engineering Graduate Program, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7
2Department of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7
3Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, ON, Canada N6A 5B7

Received 2 January 2012; Accepted 1 March 2012

Academic Editor: Kibret Mequanint

Copyright © 2012 Gregory J. Zilinskas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.