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International Journal of Polymer Science
Volume 2012 (2012), Article ID 827967, 10 pages
Research Article

A Novel Approach to Design Chitosan-Polyester Materials for Biomedical Applications

1N. S. Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, 70 Profsoyuznaya Street, Moscow 117393, Russia
2N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina Street, Moscow 119334, Russia
3Centre Interfacultaire des Biomatériaux, University of Liege, B6c, 4000 Liège, Belgium

Received 26 November 2011; Accepted 12 March 2012

Academic Editor: Kibret Mequanint

Copyright © 2012 Tatiana A. Akopova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel approach to design chitosan-polyester materials is reported. The method is based on mechanical activation and effective intermixing of the substrates under high pressure and shear deformation in the course of solid-state reactive blending. The marked departure of this approach from previous practice resides on exploitation of a variety of chemical transformations of the solid polymers that become feasible under conditions of plastic flow. Low temperatures (above Tg but below the melting points of the crystalline polymers) are maintained throughout the process, minimizing mechanical and oxidative degradation of the polymers. Morphology as well as structural, mechanical, and relaxation properties of those prepared blends of chitosan with semicrystalline poly(L,L-lactide) and amorphous poly(D,L-lactide-co-glycolide) has been studied. Grafting of polyester moieties onto chitosan chains was found to occur under employed pressures and shear stresses. The prepared polymer blends have demonstrated an amphiphilic behavior with a propensity to disperse in organic solvents that widens possibilities to transform them into promising materials for various biomedical applications.