Enzyme-Mediated Ring-Opening Polymerization of Pentadecalactone to Obtain Biodegradable Polymer for Fabrication of Scaffolds for Bone Tissue Engineering

Table 4

EMROP of pentadecalactone. Dependence of reaction time, yield, and intrinsic viscosity of resulting products on reaction temperature.

Sample number	T, °C	Time, h	Yield, %	[η], dL/g	𝑀𝑤×10^−3 (GPC)*	𝑀𝑤/𝑀𝑛 *
10	35	6.0	3	—	—	—
11	45	2.0	87	0.30	—	—
12	55	1.0	87	0.54	39.3	1.78
13	65	1.5	85	0.56	29.1	1.58
14	75	3.0	89	0.59	—	—
15	85	3.0	90	0.75	—	—
16	95	5.0	86	0.79	—	—
17	105	2.5	91	1.02	88.0	1.65
18	115	2.0	84	0.89	—	—

∗Here and further, the value corresponds to MW of a major eluted peak related to preliminary built calibration curve (polystyrene standards). Conditions: [M]/[E] = 10/1 wt./wt., [PDL] = 50 wt.%.