Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems

<div>Representation of the functionalization of polyethylene glycol and synthesis of pseudopolyrotaxane and finally primary drug delivery system. TsCl/CH<sub>2</sub>Cl<sub>2</sub>/NEt<sub>3</sub>/45° (a), thymine/KOH/DMF/H<sub>2</sub>O/2 days/70° (b), cyclodextrin/r.t/3 h (c), KOH/H<sub>2</sub>O (1d), fluorescein/DMF/24 h/r.t (2d).</div>

International Journal of Polymer Science

sch1

Scheme 1

Scheme 1: Fully Supramolecular Polyrotaxanes as Biphase Drug Delivery Systems 