Review Article
Thiomers: A Blessing to Evaluating Era of Pharmaceuticals
Table 2
Thiomers with their effect on mucoadhesion [
11].
| Thiomer | Increase in mucoadhesive strength |
| Chitosan iminothiolane | 250 times | Polyacrylic acid-cysteine | 100 times | Polyacrylic acid-homocysteine | Approx. 20 times [21] | Chitosan thioglycolic acid | 10 times | Chitosan-thioethylamidine | 9 times | Alginate cysteine | 4 times | Poly methacrylic acid-cysteine | Improved cohesiveness and mucoadhesion [42, 43] | Sodium carboxy methyl cellulose-cysteine | Increased mucoadhesion | Gellan gum-2-iminothiolane | Increased mucoadhesion [44] | Carbopol 980 | Increased mucoadhesion [45] | Hyaluronicacid-L-cysteine | Increased mucoadhesion [46] | Carboxymethyl hyaluronic acid | Improved cohesiveness and mucoadhesion [47] | Poly(ethylene glycol)-glutathione | Improved drug delivery [48, 49] | Sodium alginate | Improved drug delivery [27] |
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