Research Article
Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying
Table 2
Mucoadhesive properties of microspheres placebo (F0) and microspheres formulations F1–F9.
| Formulation | Type of adhesive layer | Gelatin | Mucin | Porcine stomach mucosa | [N] | [µJ] | [N] | [µJ] | [N] | [µJ] |
| F0 | 0.9 ± 0.3 | 362.9 ± 1.8 | 1.1 ± 3.7 | 583.4 ± 1.5 | 1.3 ± 1.3 | 779.5 ± 2.4 | F1 | 0.5 ± 0.2 | 237.5 ± 1.0 | 0.5 ± 0.2 | 275.1 ± 1.6 | 0.7 ± 0.1 | 428.0 ± 2.6 | F2 | 0.5 ± 0.2 | 203.0 ± 0.6 | 0.5 ± 0.3 | 207.2 ± 0.5 | 0.7 ± 0.2 | 360.9 ± 1.3 | F3 | 0.4 ± 0.3 | 179.5 ± 0.4 | 0.5 ± 0.4 | 179.5 ± 0.1 | 0.7 ± 0.1 | 272.3 ± 0.5 | F4 | 0.5 ± 0.2 | 392.8 ± 2.1 | 0.6 ± 0.2 | 410.0 ± 2.8 | 0.8 ± 0.2 | 681.6 ± 3.9 | F5 | 0.4 ± 0.2 | 264.0 ± 0.3 | 0.6 ± 0.3 | 367.7 ± 1.5 | 0.7 ± 0.3 | 560.3 ± 4.1 | F6 | 0.5 ± 0.2 | 238.3 ± 0.5 | 0.6 ± 0.3 | 342.3 ± 2.9 | 0.6 ± 0.2 | 467.5 ± 1.7 | F7 | 0.5 ± 0.3 | 319.4 ± 1.5 | 0.6 ± 0.2 | 501.0 ± 3.1 | 0.9 ± 0.1 | 768.2 ± 5.4 | F8 | 0.5 ± 0.2 | 303.7 ± 1.3 | 0.7 ± 0.4 | 489.6 ± 3.8 | 0.8 ± 0.2 | 692.1 ± 4.6 | F9 | 0.4 ± 0.1 | 234.2 ± 0.6 | 0.7 ± 0.3 | 441.8 ± 2.3 | 0.6 ± 0.3 | 657.7 ± 4.3 |
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Maximum detachment force and work of adhesion.
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