Enhancing Antidepressant Effect of Poloxamer/Chitosan Thermosensitive Gel Containing Curcumin-Cyclodextrin Inclusion Complex

Table 2

Effect of thermoreversible gel on reserpine-induced ptosis, akinesia, and hypothermia.

Treatment	Dose (mg/kg)	Ptosis mean score	Akinesia (mice number)	Rectal temperature (°C)
Control	-	0	0	37.3 ± 0.54
Reserpine	2.0	2.00 ± 0.67	9	34.75 ± 0.78
Fluoxetine hydrochloride	15	1.10 ± 0.32	7	35.91 ± 0.53
Curcumin	15	1.82 ± 0.97	8	35.11 ± 0.98
Thermoreversible gel	0.18	1.20 ± 0.63	8	35.69 ± 1.02
	0.36	1.10 ± 0.74	7	36.25 ± 1.09
	0.72	1.00 ± 0.47	6	36.7 ± 0.82

compared with control group; , compared with reserpine.