Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

Figure 3

Polyelectrolyte multilayer film prevents biofilm formation. (a) Blank silicon substrate. Uncoated substrate is almost completely covered by Staphylococcus aureus. (b) (Poly 2/alginic acid/ponericin G1/alginic acid)₇₅ film. The substrate is completely void of bacteria, showing 100% inhibition of S. aureus attachment on substrates coated with alginic acid films. (c) (Poly 2/chondroitin sulfate/ponericin G1/chondroitin sulfate)₇₅ film. (d) (Poly 2/dextran sulfate/ponericin G1/dextran sulfate)₇₅ film. (Scale bars: 200 μm). (Four films and controls were examined; the experiment was repeated three times.) Reprinted with permission from ref [86]. Copyright 2010 Elsevier.

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