Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

Figure 5

Functionalization of polyurethane (PU) catheter with AMP-brush coating. The catheter was initially treated with allylamine to generate a surface layer containing amine group. This was followed by a reaction with epoxy containing atom transfer radical polymerization (ATRP) initiator to generate polymerization initiating sites. Poly (N,N′-dimethylacrylamide (PDMA)-co-N-(3-aminopropyl) methacrylamide hydrochloride (APMA) brushes were grown from these initiator modified PU catheter by surface initiated ATRP (SI-ATRP). The sulfhydryl group of C-terminal cysteine peptides E6 (sequence RRWRIVVIRVRRC) was used tether it to the PDMA-co-APMA brush functionalized with iodoacetic acid N-hydroxysuccinimide ester. Reprinted with permission from ref [90]. Copyright 2017 Elsevier.