Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

Scheme 1

Different macromolecular structures, self-assembly behaviors, and applications of peptide–polymer conjugates (PPC). (a) PPC is used as wound dressing to help inhibit bacteria and promote wound healing. (b) PPC is applied on bone tissue repair to help bone tissue repair by inhibiting bacteria and delivering drugs. (c) PPC is served as antibacterial coatings on medical devices, such as urinary catheters and contact lenses, to avoid infection caused by the use of medical devices. (d) PPC assists cancer treatment. It can destroy tumor cell membrane through safe and efficient delivery of AMPs and electrostatic interaction. (e) PPC for the use of nerve repair to remyelinate demyelinated damaged nerve fibers and avoid infection. (f) For oral health maintenance, PPC is used as the antibacterial coating of teeth helps prevent dental caries.