Review Article

Peptide–Polymer Conjugates: A Promising Therapeutic Solution for Drug-Resistant Bacteria

Table 1

Inhibition effect of PPC on different bacteria in different application scenarios.

Application scenariosPPCBacterial speciesPMIDDate and references

Wound dressingAMP–CBP (cellulose binding peptide) immobilized on cellulose membranes or electrospun fibers.Staphylococcus aureus and Pseudomonas aeruginosa321599272020 [83]
The Tet213-conjugated ALG/HA/COL wound dressing.Escherichia coli and S. aureus31421742019 [84]
The engineered MeTro/GelMA-Tet213 hydrogels.Methicillin resistant S. aureus, and E. coli285790652017 [71]
Bone tissue repairThree layers of vertically oriented TiO2 nanotubes, a thin layer of calcium phosphate coating, and a phospholipid (POPC) film were impregnated with a potent broad-spectrum AMP (HHC-36).S. aureus and P. aeruginosa236803632013 [85]
Polyelectrolyte multilayer film containing AMP (ponericin G1).S. aureus200049672010 [86]
Antibacterial vesicles based on peptide-mimetic alternating copolymers.E. coli and S. aureus290204502017 [87]
Antibacterial coating for medical devicesAntimicrobial peptide melimine coating for titanium.S. aureus and P. aeruginosa268718902016 [88]
Melimine-coated contact lenses.S. aureus and P. aeruginosa247593272014 [89]
Anti-adhesive antimicrobial peptide coating of catheters.P. aeruginosa, S. aureus, and Staphylococcus saprophytic279142682017 [90]
Hydrogel coatings containing AMP (HHC-36).S. aureus, Staphylococcus epidermidis, P. aeruginosa, and E. coli281405642017 [91]
Tumor treatmentMelittin-lipid nanoparticles.321118282020 [92]
Nerve repairHydrogels grafted with poly(L-lysine).222512482012 [93]
Oral applicationThe peptide of Ser(p)–Ser(p)–polyphemusin I (DPS-PI).Streptococcus mutans309290872019 [94]
A peptide-based 2-tier protective system for dental resin composite restorations.Biofilm of oral microflora307539422019 [95]
Dental adhesives copolymerized with AMP–polymer conjugates.S. mutans338341662020 [96]