Electrospun Fibers: Versatile Approaches for Controlled Release Applications

Table 1

Summarized information about different types of electrospinning.

Electrospinning type	Suggested molecules for delivery	Advantages	Limitations
Blend electrospinning	Small molecules	The simplest method of electrospinning	Harsh process for sensitive molecules
Sequential electrospinning	Small molecules	Relatively simple method, multiphasic delivery	Harsh process for sensitive molecules independent non-protected layers
Coaxial/multiaxial electrospinning	Wide range of drugs, such as small molecules, proteins, and RNA	Possibility to form core–shell nanofibers from miscible and immiscible polymers high loading capacity less harsh process multiphasic delivery with complex release profiles	Optimization of multineedle methods low production rate compatibility of core and shell fluids
Emulsion electrospinning	Wide range of drugs, such as small molecules, proteins, and RNA	Single nozzle formation of core–shell structure	Choosing polymers with sufficient interfacial tension needed care for preparation of emulsion
Side-by-side electrospinning	Small molecules	Relatively simple method, multiphasic delivery	Independent non-protected layers