Characteristics of Interstitial Fibrosis and Inflammatory Cell Infiltration in Right Ventricles of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension

Table 1

General patient characteristics.

	SScPAH	IPAH	Control
	𝐍=𝟓	𝑁=9	𝑁=4
Age, yrs	47±4	47±4	31±4
Male/Female no.	1/4	2/7	−−−
Survival	1.1±0.5	3.7±0.9	−−−
Heart rate	85±3	78±5
mPpa, mmHg	46±7	62±4
PCWP, mmHg	6±2	5±2
PVR, dynes·s·cm^−5	1221±691	1157±144
CI, l/min·m^2	2.3±0.9	2.3±0.5
Systolic blood pressure	105±2	118±8
Diastolic blood pressure	69±6	73±5
TLC, %	89±5	92±5
DLCO, %	42±6	64±6
Therapy at time of death
Prostacycline (𝑛)	4	7
ERA (𝑛)	1	2
PDE-5 inhibitor (𝑛)	1	0
ABS		1

Values expressed as mean ± SE or otherwise as stated. Abbreviations: ABS: atrial balloon septostomy;   CI: cardiac index; DLCO%: percentage of predicted of the diffusion capacity of the lung for carbon monoxide; ERA: endothelin receptor antagonist; mPpa: mean pulmonary artery pressure; PCWP: pulmonary capillary wedge pressure; PDE-5: phosphodiesterase 5; PVR: pulmonary vascular resistance; IPAH: idiopathic pulmonary arterial hypertension; SScPAH: systemic sclerosis-associated pulmonary arterial hypertension; TLC%: percentage of predicted total long capacity.