Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

Figure 4

Schematic illustrating that ER resident and cell surface dimers are not related. ER resident dimers can form via C67-C67 or C164-C164 disulfide bonds, but do not transit out off the ER. Cell surface dimers are thought to form following the recycling of fully folded HLA-B27 cell surface molecules through the endocytic pathway before being reexpressed as dimers mediated by C67-C67 interactions.