The Th17/IL-23 Axis and Natural Immunity in Psoriatic Arthritis

Figure 1

Th17/IL-23 axis, environmental factors and psoriatic arthritis. Environmental factors, such as microbial infections, Koebner phenomenon, trigger Th17/IL-23 and CD8+ T cells activation. Pro-inflammatory cytokines secreted by activated T cells promote inflammation and induce acanthosis, parakeratosis, and spondyloarthropathy.