Clinical Study

Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease

Table 5

Recounting in each areas of 17 samples containing both fibrotic and nonfibrotic parts. All patients were diagnosed with IgG4-RD but had biopsy specimens that were too small (samples 1–14) or with relatively large fibrotic areas inadequate to diagnose IgG4-RD (samples 15–17). All samples had >10 IgG4+ cells per HPF.

TissueFibrosis+Fibrosis−

(1) Pancreas76.6%94.0%
(2) Submandibular gland75.4%89.2%
(3) Submandibular gland72.1%73.0%
(4) Submandibular gland72.1%97.3%
(5) Submandibular gland71.8%99.1%
(6) Pancreas67.7%95.0%
(7) Labial salivary glands65.0%70.8%
(8) Lung58.9%94.4%
(9) Submandibular gland49.2%68.9%
(10) Gall bladder48.6%94.0%
(11) Bile duct46.8%95.0%
(12) Submandibular gland46.2%74.1%
(13) Orbit44.2%94.4%
(14) Submandibular gland43.6%95.0%
(15) Submandibular gland33.3%95.0%
(16) Submandibular gland25.9%51.5%
(17) Labial salivary glands8.0%76.2%