Clinical Study
Immunohistochemical Characteristics of IgG4-Related Tubulointerstitial Nephritis: Detailed Analysis of 20 Japanese Cases
Table 2
Histologic features of IgG4-related tubulointerstitial nephritis.
| | | | IgG4 IHC | | Glomerular | IF TBM | IF TBM | IF TBM | IF GL | IF GL | IF GL | IF GL | EM TBM | EM GL | | Pt. no. | Age/gender | (cells per hpf) | IgG4/IgG | Lesion | IgG | C3 | C1q | IgG | IgA | C3 | C1q |
| | 1 | 76/F | 50 | 81% |
−
|
−
|
+
|
−
|
−
|
−
|
−
|
−
|
−
|
−
| | 2 | 70/M | 19 | 38% |
−
| NA | NA | NA | NA | NA | NA | NA |
+
|
−
| | 3 | 59/M | 57 | 54% |
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
| NA |
−
| | 4 | 63/M | 37 | 46% |
−
|
−
|
+
|
+
|
−
|
−
|
−
|
−
|
−
|
−
| | 5 | 58/M | 21 | 81% |
−
| NA | NA | NA |
−
|
−
|
−
| NA | NA |
−
| | 6 | 58/M | 156 | 77% |
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
| | 7 | 75/M | 25 | 18% |
−
|
−
|
−
|
−
| NA | NA | NA | NA |
+
|
−
| | 8 | 68/M | 17 | 40% |
−
|
−
|
−
|
−
|
+
|
−
|
+
|
−
|
−
|
−
| | 9 | 75/M | 28 | 64% |
−
|
+
|
+
|
−
|
−
|
−
|
−
|
−
| |
−
| | 10 | 55/M | 49 | 55% |
−
|
−
|
−
|
−
| |
−
|
−
|
−
|
−
|
−
| | 11 | 69/M | 30 | 51% |
−
|
−
|
−
|
−
|
+
|
−
|
−
| |
+
|
−
| | 12 | 80/M | 10 | 90% | MPGN | NA | NA | NA | |
−
| |
+
| NA |
+
| | 13 | 68/M | 28 | 38% | IgA GN |
−
|
+
|
−
|
−
| | | | NA | NA | | 14 | 79/M | 42 | 41% | EC |
−
|
+
|
+
|
−
|
−
|
−
|
−
|
+
|
−
| | 15 | 69/M | 73 | 57% | EC |
−
|
−
|
−
|
−
|
−
|
+
|
−
|
−
|
−
| | 16 | 72/M | 51 | 58% | HSPN | NA | NA | NA | |
+
| |
−
| NA |
+
| | 17 | 75/F | 62 | 40% | HSPN |
−
|
−
|
−
|
−
|
+
| |
−
|
−
|
+
| | 18 | 83/M | 25 | 43% | MGN |
+
|
+
|
−
|
+
|
−
|
+
|
−
|
+
|
+
| | 19 | 60/M | 68 | 42% | MGN |
−
|
−
|
−
| |
−
|
−
|
−
|
−
|
+
| | 20 | 78/M | 28 | 45% | MGN |
−
|
+
|
−
|
−
|
−
|
−
|
−
|
−
|
+
|
|
|
Abbreviations: EC: endocapillary hypercellularity; EM: electron microscopy; GL: glomeruli; hpf: high-power field; HSPN: Henoch-Schönlein purpura nephritis; IF: immunofluorescence; IgA GN: IgA nephropathy; IHC: immunohistochemistry; MGN: membranous glomerulonephritis; MPGN: membranoproliferative glomerulonephritis; NA: not available; Pt.: patient; TBM: tubular basement membranes.
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