Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders

Table 1

Clinical data in 16 cases with IgG4-related orbital disease.

Case number	Age	Sex	Orbital lesions	Lesions other than orbit	Serum IgG (mg/dL)	Serum IgG4 (mg/dL)	IgG4/IgG (%)	IgG4 + cells /HPF	Serum IgE (IU/mL)	Therapy
1	62	F	LG	None	1690	29	2	43	14	None
2	66	M	LG	SG	1960	164	8	143	1621	None
3	56	F	LG	Lung lesion	1671	194	12	46	254	Steroid
4	46	F	LG, EOM	SG, retroperitoneal fibrosis	1350	209	15	92	170	Steroid
5	41	F	LG	Sinusitis	1554	260	17	62	178	None
6	53	F	LG	SG	2260	359	16	58	611	Steroid
7	65	M	LG, EOM, ION	Sinusitis, submandibular lymphadenopathy	1448	404	28	98	3374	Steroid
8	60	M	LG, EOM, OPN, SON, ION	SG, neck skin nodule	1220	463	38	82	4608	Steroid
9	64	F	LG	SG, neck lymph nodes TB	1820	486	27	83	90	Steroid
10	66	M	LG	SG, lung lesion, axillary lymphadenopathy	1900	575	30	48	151	Steroid
11	44	M	LG, OPN, ION	None	1322	599	45	63	351	Steroid
12	76	F	LG	Nephritis	2860	769	27	58	428	Steroid
13	60	M	LG	SG,	1952	886	45	48	575	Steroid
14	45	M	LG, EOM, ION	Lung lesions, sinusitis	2260	914	40	74	72	Steroid
15	52	M	LG	SG	3440	949	28	50	973	Steroid
16	47	F	LG, SON, ION	SG	2350	1000	43	55	183	Steroid
				Normal range	870–1700	<135	<7	<10	<250

LG: lacrimal gland, EOM: extraocular muscle, OPN: optic nerve, SON: supraorbital nerve, ION: infraorbital nerve, SG: salivary gland.