Review Article
Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus
Table 1
SLE/SS-related SNP in TRIM21 gene.
| | Location (position)* | Reference SNP ID | Nucleotide change | Genotype frequency (%) | Value | Reference |
| | 5′-UTR | rs5030767 | | Ab(+) pSS | HC | | | | (4595) | | | () | () | | | | | C/C | 60.5 | 83.3 |
0.029 |
[22] | | | C/T | 34.2 | 13.9 | | | | | T/T | 5.3 | 2.8 | | |
| | Intron 1 | rs7947461 | | Ab(+) pSS | Ab(−) pSS | | | | (7216) | | | () | () | | | | | A/A | 25.6 | 4.3 |
0.028 |
[23] | | | A/G | 56.4 | 52.2 | | | | | G/G | 17.9 | 43.5 | | |
| | Intron 1 | rs660 | | SLE | HC | | | | (7219) | | | () | () | | | | | C/C | 3.8 | 34.5 |
<0.0005 |
[20, 21] | | | C/T | 26.9 | 44.8 | | | | | T/T | 69.2 | 20.7 | | |
| | Intron 1 | rs5030768 | | Ab(+) pSS | HC | | | | (7649) | | | () | () | | | | | A/A | 57.9 | 80.5 |
0.038 |
[22] | | | A/G | 34.2 | 16.7 | | | | | G/G | 7.9 | 2.8 | | |
| | Intron 3 | rs915956 | | Ab(+) pSS | HC | | | | (9571) | | | () | () | | | | | C/C | 44.7 | 84.7 |
0.00003 |
[22] | | | C/T | 52.6 | 12.5 | | | | | T/T | 2.6 | 2.8 | | |
| | 3′-UTR | rs4144331 | | Ab(+) pSS | HC | | | | (12986) | | | () | () | | | | | C/C | 71.1 | 87.5 |
0.033 |
[22] | | | C/A | 28.9 | 12.5 | | |
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*Position in the gene according to GenBank accession no. UO1882. UTR, untranslated region; Ab(+), anti-TRIM21 antibody-positive; pSS, primary SS, HC, healthy control; Ab(−), anti-TRIM21 antibody-negative.
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