Clinical Study
The Association of IL-12b Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population
Table 1
Genotype and allele frequencies of IL-12b SNP rs6887695 in SLE cases and controls*.
| | | Genotype frequency, no. (%) | Allele frequency, no. (%) | | SNP,
population | No. of subjects | Major homozygote | Hetero-zygote | Minor homozygote | P | Major allele | Minor allele | P | OR (95% CI) |
| | Genotype or allele | | GG | GC | CC | | G | C | | | | Cases | 297 | 107 (36.0) | 153 (51.5) | 37 (12.5) | 0.019 | 367 (61.8) | 227 (38.2) | 0.031 |
0.78 (0.63–0.98) | | Controls | 351 | 114 (32.5) | 164 (46.7) | 73 (20.8) | 392 (55.8) | 310 (44.2) |
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*SNP: single-nucleotide polymorphism; SLE: systemic lupus erythematosus; OR: odds ratios; 95% CI: 95% confidence interval.
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