Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups
Table 1
Hormonal values in males of reported assays and normalized, imputed values in females to full sample sizes.
Hormones assayed and statistical values
Reported assay values in males
Normalized and imputed values in females
pre-RA ()
Control ()
Total ()
pre-RA ()
Control ()
Total ()
17-OH Pregnenolone:
Mean (nmol/L) ± SE
Median; IQR
11.0; 8.7–14.6
10.2; 7.3–15.2
10.2; 7.7–15.0
5.7; 4.2–8.8
5.7; 4.4–7.9
5.7; 4.4–8.2
17-OH Progesterone:
Mean (nmol/L) ± SE
Median; IQR
4.5; 3.5–6.0
4.7; 3.1–6.3
4.7; 3.2–6.2
3.6; 1.7–6.1
3.0; 1.9–5.7
3.1; 1.9–5.9
Dehydroepiandrosterone:
Mean (nmol/L) ± SE
Median; IQR
7.7; 3.9–9.7
7.2; 4.8–10.3
7.2; 4.7–10.1
14.8; 11.5–19.2
15.9; 12.5–20.8
15.6; 12.4–19.7
Androstenedione:
Mean (nmol/L) ± SE
Median; IQR
2.2; 1.4–3.0
2.2; 1.5–2.9
2.2; 1.5–2.9
6.6; 5.3–8.3
7.2; 6.2–8.8
7.1; 6.0–8.6
Testosterone (T):
Mean (nmol/L) ± SE
Median; IQR
17.8; 13.3–24.3
17.4; 13.7–23.3
17.8; 13.6–23.5
2.3; 1.8–2.9
2.3; 1.8–2.9
2.3; 1.8–2.9
Estradiol (E2):
Mean (pmol/L) ± SE
Median; IQR
68; 49.0–84.3
66.0; 48.0–80.3
66.0; 48.0–81.0
168; 83–276
176; 80–278
173; 81–278
E2/T ratio ()
Mean ± SE
Median; IQR
4.0; 2.7–4.9
3.4; 2.5–5.0
3.5; 2.6–5.0
76.5; 27.7–151
80.2; 37.6–138
78.8; 35.4–138
Cortisol:
Mean (nmol/L) ± SE
Median; IQR
257; 161–381
255; 186–382
255; 184–369
241; 143–329
205; 155–285
216; 155–286
DHEA sulfate (DHEAS):
Mean (mol/L) ± SE
Median; IQR
6.2; 3.8–11.0
6.8; 4.8–8.8
6.8; 4.6–8.9
2.3; 1.5–3.5
2.6; 1.6–3.9
2.5; 1.6–3.8
Luteinizing Hormone (LH):
Mean (IU/L) ± SE
Median; IQR
5.5; 4.0–7.2
5.1; 4.0–6.9
5.1; 4.0–7.0
19.6; 4.3–36.2
15.7; 5.4–39.5
17.1; 5.3–37.9
Prolactin (PRL):
Mean (g/L) ± SE
Median; IQR
7.6; 4.0–11.4
6.1; 4.6–9.0
6.3; 4.6–9.7
9.5; 8.1–13.3
10.4; 8.0–13.4
10.1; 8.1–13.4
Mean ages ± SEs
SE: standard error of mean, IQR: interquartile range of median. , as previously reported [13].
