Possible Involvement of Foxp3+ Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid
Figure 7
Representative immunostaining of Foxp3 in the pancreases (a) and the ratios of Foxp3/mono (Foxp3-positive cells/infiltrated mononuclear cells) in the pancreases (b) of poly I:C-treated MRL/Mp mice at the age of 10–20 weeks and Cerulein-, Ligation-, and -treated mice at the same age. Abundant infiltration of Foxp3-positive cells was found among the lymphoid infiltrates in MRL/Mp mice pancreases, but not in Cerulein-treated mice. In Ligation- and -treated mice, Foxp3 immunostaining of the pancreas showed infiltration of few Foxp3-positive cells. The Foxp3/mono ratios in MRL/Mp mice were significantly increased compared with Cerulein-, Ligation-, and -treated mice. ×100 magnification (large panel), ×400(inset). Data are expressed as ; .
