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International Journal of Rheumatology
Volume 2013 (2013), Article ID 610393, 8 pages
http://dx.doi.org/10.1155/2013/610393
Review Article

The Role of Klebsiella in Crohn’s Disease with a Potential for the Use of Antimicrobial Measures

1Analytical Sciences Group, King’s College, 150 Stamford Street, London SE1 9NH, UK
2Departments of Microbiology and Pathology, King Edward VII Memorial Hospital, Hamilton, Bermuda

Received 22 July 2013; Accepted 4 September 2013

Academic Editor: Ruben Burgos-Vargas

Copyright © 2013 Taha Rashid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is a general consensus that Crohn’s disease (CD) develops as the result of immune-mediated tissue damage triggered by infections with intestinal microbial agents. Based on the results of existing microbiological, molecular, and immunological studies, Klebsiella microbe seems to have a key role in the initiation and perpetuation of the pathological damage involving the gut and joint tissues in patients with CD. Six different gastroenterology centres in the UK have reported elevated levels of antibodies to Klebsiella in CD patients. There is a relationship between high intake of starch-containing diet, enhanced growth of gut microbes, and the production of pullulanases by Klebsiella. It is proposed that eradication of these microbes by the use of antibiotics and low starch diet, in addition to the currently used treatment, could help in alleviating or halting the disease process in CD.