AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis
Table 5
Effect of erosion, osteitis, and synovitis at baseline on subsequent progression of erosion.
MRI feature
Number of bones involved
RAMRIS Erosion Scores Mean (SD)
% erosion
Baseline
24 weeks
−ERO
813
0
0.02 (0.13)
2.7
+ERO
432
1.02 (0.63)
1.09 (0.67)
12.0
−OST
1017
0.24 (0.50)
0.27 (0.55)
4.1
+OST
228
0.89 (0.77)
0.95 (0.78)
14.0
−SYN
465
0.21 (0.50)
0.22 (0.54)
2.8
+SYN
679
0.47 (0.66)
0.52 (0.70)
8.2
+ERO −OST
251
0.95 (0.57)
1.03 (0.63)
10.0
+ERO +OST
181
1.12 (0.70)
1.17 (0.71)
14.9
+ERO −SYN
87
1.10 (0.59)
1.18 (0.65)
12.6
+ERO +SYN
318
1.01 (0.64)
1.07 (0.67)
12.3
Based on 1245 bones evaluable for ERO or OST and 1144 bones evaluable for adjacent SYN. progression defined as ≥0.5; ERO: erosion; OST: osteitis; SYN: synovitis.
