Sequential Spectrophotometric Method for the Simultaneous Determination of Amlodipine, Valsartan, and Hydrochlorothiazide in Coformulated Tablets

Table 1

Determination of AML, VAL, and HCT in laboratory prepared mixtures by the proposed method.

Concentration (𝜇g/mL)			Proposed method recovery %^a
AML	VAL	HCT	AML	VAL	HCT
4^b	40	6.25	101.01	101.38	97.78
12	40	6.25	100.91	98.20	100.74
20	40	6.25	99.53	100.04	100.74
12	20	6.25	101.37	100.16	99.26
12	4	6.25	101.55	97.34	100.74
12	20	12.5	101.22	100.12	101.48
4	4	12.5	98.26	99.82	100.74
Mean			100.55	99.58	100.21
SD			1.208	1.357	1.262
RSD%			1.201	1.363	1.260

aAverage of three determinations.
bThe ratio of dosage form.