Table 1: Clinicopathologic characteristics of hereditary versus sporadic breast and ovarian cancer.

Breast cancer Ovarian cancer Average age of diagnosis BRCA1 ↓ BRCA1 ↓ BRCA2 ↔ BRCA2 ↔ Pathological features ↓ differentiation ↔ grade, stage ↑ bilateral tumours ? ↑ papillary serous serology ↑ # lymph nodes Receptor status BRCA1: ↑ ER−/PR−/HER2− BRCA2: similar to sporadic tumours Survival ↓ progression free-survival ↑ progression-free survival ↓ overall survival ↑ overall survival