Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review

Table 1

Clinicopathologic characteristics of hereditary versus sporadic breast and ovarian cancer.

	Breast cancer	Ovarian cancer
Average age of diagnosis	BRCA1 ↓	BRCA1 ↓
	BRCA2 ↔	BRCA2 ↔
Pathological features	↓ differentiation	↔ grade, stage
	↑ bilateral tumours	? ↑ papillary serous serology
	↑ # lymph nodes
Receptor status	BRCA1: ↑ ER−/PR−/HER2−
	BRCA2: similar to sporadic tumours
Survival	↓ progression free-survival	↑ progression-free survival
	↓ overall survival	↑ overall survival