Review Article
Clinical Considerations of BRCA1- and BRCA2-Mutation Carriers: A Review
Table 2
Clinical features that warrant referral for genetic testing for BRCA1/2 mutations.
| (i) Early-onset breast cancer, usually defined as before age 50 or 45 | | (ii) Ovarian, fallopian tube or primary peritoneal cancer | | (iii) Individuals with two or more primary breast cancers, or breast and ovarian cancer in the same individual | | (iv) Male breast cancer | | (v) Two or more individuals in the family with breast and/or ovarian cancer | | (vi) Ashkenazi Jewish ancestry | |
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