Familial Renal Cancer: Molecular Genetics and Surgical Management
Figure 5
FLCN pathway. (a) FLCN is the gene associated with BHD. Normal FCLN protein complexes with FNIP1, FNIP2, and AMPK. This complex is phosphorylated by a rapamycin-sensitive kinase (mTORC1). (b) When FLCN is altered, it fails to complex and allows activation of AKT, mTORC1, and mTORC2. (From Hasumi et al. [69], with permission.)
