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International Journal of Surgical Oncology
Volume 2012 (2012), Article ID 416418, 5 pages
http://dx.doi.org/10.1155/2012/416418
Clinical Study

Extramammary Paget’s Disease: 20 Years of Experience in Chinese Population

Division of Plastic & Reconstructive Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong

Received 9 June 2011; Revised 30 November 2011; Accepted 4 December 2011

Academic Editor: Frank A. Frizelle

Copyright © 2012 Jimmy Yu Wai Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To examine the results of treatment of Extramammary Paget’s disease (EMPD) in ethnic Chinese. Method. Between 1990 and 2010, patients treated for EMPD were reviewed. Data were analyzed retrospectively. Results. Forty-eight patients were treated by surgical resection. Local recurrence rate was 14.6%. The postresection defects were repaired by primary closure (8.3%), partial thickness skin graft (72.9%), or local/regional flaps (18.8%). Dermal invasion was found in 9 patients (18.8%). Seven patients (14.6%) developed regional lymph node metastasis (concurrent with surgery, 𝑛 = 1 ; subsequent to surgery, 𝑛 = 6 ), and 3 patients (6.3%) had systemic metastasis after surgery. The presence of dermal invasion was associated with significantly higher incidence of regional lymph nodes and systemic metastasis. The incidence of associated internal malignancy was 8.3%. Conclusion. The mainstay of treatment for EMPD is surgery. Pathological dermal invasion increases the chance of regional lymph node as well as systemic metastasis. The association with internal malignancy warrants preoperative endoscopic examination in all patients.