Radiotherapy after Conservative Surgery in Ductal Carcinoma In Situ of the Breast: A Review

Table 1

Characteristics of the prospective randomized trials.

	NSABP-B17	EORTC 10853	SweDCIS	UK/ANZ DCIS
Entry dates	1985–1990	1986–1996	1987–1999	1990–1998
Pts. randomized	818	1010	1067	1030
CS	405	503	533	508
CS + RT	413	510	534	522
Mammographic detection	80.4%	71%	78.7%	NS
Central pathological review	76%	85%	26%	0%
Negative margins required	Yes	Yes	No	Yes
Margins free	78%	83%	80%	100%
RT dose	50 Gy/25 fr.	50 Gy/25 fr.	50–54 Gy/25–27 fr.	50 Gy/25 fr.
Boost	10 Gy/5 fr. (9% of pts.)	10 Gy/5 fr. (5% of pts.)	NR	NR

Legend: Pts: patients; NS: not specified; NR: not recommended; RT: radiotherapy; CS: conservative surgery; fr.: fractions.