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Patient | Age | Sex | Presenting symptoms | Symptom duration | Primary disease | Metastatic lesion | Location | Management | Outcome |
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1 | 77 | m | Retroorbital pain Left nerve III palsy | 4 months | Prostate cancer | Prostate cancer | CS and sella extending to inferior orbital fissure and upper clivus | Transsphenoidal biopsy, radiotherapy, chemotherapy | Stable neurological findings at two months |
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2 | 82 | f | Hearing loss Facial pain Numbness in cranial nerve V1, V2 | Several weeks | Breast cancer | Breast cancer | Petrous apex extending to Meckel’s cave, lateral CS, and IAC | Transcranial biopsy, radiotherapy, chemotherapy | N/A |
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3* | 79 | m | Cranial nerve III and VI palsies | Several weeks | Prostate cancer | Melanoma | Bilateral CS, sella, clivus, and posterior nasal cavity | Transsphenoidal biopsy | N/A |
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4 | 21 | m | Horner's syndrome Facial pain | 1 month | Osteosarcoma Renal cell cancer | Renal cell cancer | CS extending to sphenoid sinus, pterygopalatine fossa, and optic canal | Radiation, chemotherapy | N/A |
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5 | 42 | f | Gait instability Headache | 1 month | Unknown | Lymphoma | Sellar/suprasellar lesion with bilateral CS, medial sphenoid wing, and clivus involvement | Transsphenoidal biopsy, chemotherapy, possible radiotherapy | N/A |
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6 | 57 | f | Decreased visual acuity Peripheral vision defect | 1 month | Breast cancer | Breast cancer | Greater sphenoid wing extending to the anterior clinoidal process with the optic nerve encasement | Transcranial decompression of optic nerve and the CS, radiotherapy with possible chemotherapy | Stable neurological findings and primary disease at one year |
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