Prolonged Therapy with Imatinib Mesylate before Surgery for Advanced Gastrointestinal Stromal Tumor Results of a Phase II Trial

Table 3

Surgical strategy before and after neoadjuvant imatinib, resection performed, and resection margins.

Patient	Number of organs planned to be resected before NAI^i (details)	Number of organs planned to be resected after NAI (details)	Changes in resection due to NAI	Number of organs resected	Resection margins
1	1^ii (with colostomy)	1^iii (no colostomy)	↓	1	R0
2	1 (STG^iv)	1 (WG^v)	↓	1	R0
3	1 (STG)	1 (WG)	↓	1	R0
4	4 (Whipple, RC^vi, kidney)	3 (Whipple, RC)	↓	3	R0
5	3 (STG, SP^vii, and PA^viii)	3 (WG, SP, and PA)	↓	3	R0
6	1 (antrectomy)	1 (antrectomy)	=	0^ix	NA^x
7	2 (stomach + liver)	2 (stomach + liver)	=	0^xi	NA
8	2 (STG + left liver)	2 (STG + left liver^xii)	=	2	R0
9	1 (liver)	1 (liver)	=	1	R0
10	4 (oesophagectomy + trachea + pericardia + vertebral body)	1 (oesophagus)	↓	1	R0
11	2 (Whipple)	2 (Whipple)	=	0^xiii	NA
12	2 (STG + PA)	1 (STG)	↓	1	R0
13	3 (STG + SP + PA)	3 (STG + SP + PA)	=	3	R0
14	1 (antrectomy)

ⁱNAI: neoadjuvant imatinib.
ⁱⁱAbdominoperineal resection.
ⁱⁱⁱLow anterior resection with primary anastomosis.
^ivSTG: subtotal gastrectomy.
^vWG: wegde gastrectomy.
^viRC: right hemicolectomy.
^viiSP: spleen.
^viiiPA: pancreas.
^ixPatient refused laparotomy.
^xNot applicable.
^xiNR: nonresectable due to multiple liver metastasis.
^xiiSemielective procedure for gastric bleeding.
^xiiiPatient refused Whipple procedure (segmental duodenal resection was not possible).