Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation
Figure 3
(a) miR-21 transcription in volume of breast tissue and corresponding serum levels in patients with significant correlation, Pearson correlation (positive correlation, correlation coefficient = 0.866, P < 0.05). (b) Different clinical invasions of breast tissue in the transcription miR-21 and TIMP3 were significantly correlated (negative correlation, correlation coefficient = −0.778, P < 0.05). (c) Different clinical invasion of breast tissue in volume of miR-21 transcription and TIMP3 protein expression was significantly correlated (negative correlation, correlation coefficient = −0.692, P < 0.05). (d) miR-21 serum levels and breast tissue volume of TIMP transcription were significantly correlated (negative correlation, correlation coefficient = −0.762, P < 0.05). (e) miR-21 serum levels and TIMP breast tissue levels of protein expressions were significantly correlated (negative correlation, correlation coefficient = −0.625, P < 0.05). (f) Different clinical invasions of breast tissue levels of TIMP3 transcription and protein expression were also correlated (positive correlation, correlation coefficient = 0.616, P < 0.05).
