Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation

Table 5

Data A	Data B	Correlation coefficient	Sig.
Tissue miR-21	Serum miR-21	0.866	0.000
Tissue miR-21	TIMP-3 mRNA	−0.778	0.000
Tissue miR-21	TIMP-3 Proteins	−0.692	0.000
Serum miR-21	TIMP-3 mRNA	−0.762	0.000
Serum miR-21	TIMP-3 Proteins	−0.625	0.000
TIMP-3 mRNA	TIMP-3 Proteins	0.616	0.000

Each of the tumor tissue and serum in the miR-21, tumor tissue miR-21 and TIMP-3 of the mRNA, tumor tissue miR-21 and TIMP-3 protein, serum miR-21 and tumor tissue of TIMP-3 mRNA, the miR-21 in serum and tumor tissue TIMP-3 protein, and tumor tissue TIMP-3 mRNA and protein do Pearson correlation analysis; correlation coefficients were 0.866, −0.778, −0.692, −0.762, −0.625, and 0.616, with statistical significance.