The Aetiology of Delay to Commencement of Adjuvant Chemotherapy following Colorectal Resection

Table 3

Cox regression analysis of factors associated with time from surgery to commencement of adjuvant chemotherapy.

	Univariate analysis			Multivariate analysis (𝑛=159)
	Hazard ratio (95% CI)	𝜒^2	𝑃	Hazard ratio (95% CI)	𝜒^2	𝑃
Age	0.993 (0.978 to 1.007)	0.973	0.324
Gender (F)	1.310 (0.937 to 1.832)	2.500	0.114
BMI	0.991 (0.961 to 1.023)	0.292	0.589
Comorbidity (Y)	1.083 (0.789 to 1.488)	0.247	0.619
Neoadjuvant therapy (Y)	0.889 (0.625 to 1.265)	0.425	0.514
Laparoscopic procedure (Y)	1.337 (0.906 to 1.973)	2.141	0.143
Stoma (Y)	0.757 (0.555 to 1.031)	3.115	0.078	0.704 (0.512 to 0.970)	4.613	0.032
Tumour size	1.002 (0.994 to 1.010)	0.180	0.672
Differentiation (poor versus well/moderate)	1.201 (0.679 to 2.122)	0.396	0.529
T stage	1.009 (0.863 to 1.179)	0.013	0.911
N stage	0.940 (0.680 to 1.299)	0.141	0.707
Lymph node ratio	0.494 (0.215 to 1.131)	2.785	0.095	0.408 (0.168 to 0.992)	3.915	0.048
Resection margin status (+)	0.917 (0.546 to 1.541)	0.107	0.744
Vascular invasion (+)	1.151 (0.816 to 1.623)	0.645	0.422
Anastomotic leak (Y)	0.304 (0.123 to 0.749)	6.701	0.010	0.352 (0.140 to 0.887)	4.907	0.027
Preoperative haemoglobin	1.006 (0.915 to 1.105)	0.013	0.908
Preoperative platelets	1.000 (0.999 to 1.002)	0.613	0.434
Preoperative neutrophils	0.977 (0.915 to 1.042)	0.518	0.472
Preoperative lymphocytes	0.966 (0.824 to 1.131)	0.187	0.666
Preoperative C-reactive protein	0.998 (0.994 to 1.001)	1.751	0.186
Preoperative albumin	1.036 (1.007 to 1.067)	5.933	0.015	1.034 (1.004 to 1.065)	4.916	0.027
Tumour site (colon versus rectum)	1.092 (0.802 to 1.487)	0.311	0.577
Emergency (Y)	0.755 (0.426 to 1.339)	0.925	0.336