Transition to Targeted Therapies Improved the Prognosis and Increased the Utilization of Medical Treatments among Patients with Synchronous Metastatic Renal Cell Cancer
Table 1
Baseline characteristics of patient population according to diagnostic period.
Baseline characteristics
Number of patients (%)
-value
Diagnostic period
Total
2005–2007
2008–2010
Total number of patients
499
478
977
Gender
0.094
M
301 (60.3%)
263 (55.0%)
564 (57.7%)
F
198 (39.7%)
215 (45.0%)
413 (42.3%)
Mean age at diagnosis (years)
68.6
68.8
68.4
0.619
ECOG
<0.001
0
23 (5.5%)
40 (8.6%)
63 (7.2%)
1
202 (48.6%)
233 (50.3%)
435 (49.5%)
2
103 (24.8%)
124 (26.8%)
227 (25.8%)
3
61 (14.7%)
59 (12.7%)
120 (13.7%)
4
27 (6.5%)
7 (1.5%)
34 (3.9%)
T stage
0.567
T1
95 (21.7%)
87 (19.0%)
182 (20.3%)
T2
69 (15.8%)
82 (17.9%)
151 (16.9%)
T3
191 (43.6%)
210 (45.9%)
401 (44.8%)
T4
83 (18.9%)
79 (17.2%)
162 (18.1%)
N stage
0.507
N0
305 (61.1%)
302 (63.2%)
607 (62.1%)
N1
194 (38.9%)
176 (36.8%)
370 (37.9%)
Number of metastatic sites
0.823
1
150 (30.1%)
135 (28.2%)
285 (29.2%)
2
159 (31.9%)
156 (32.6%)
315 (32.2%)
≥3
190 (38.1%)
187 (39.1%)
377 (38.6%)
Metastatic sites
Distant lymph nodes
112 (22.4%)
133 (27.8%)
245 (25.1%)
0.052
Lungs
297 (59.5%)
302 (63.2%)
599 (61.3%)
0.240
Bone
154 (30.9%)
159 (33.3%)
313 (32.0%)
0.421
Adrenal gland
101 (20.2%)
87 (18.2%)
188 (19.2%)
0.419
Liver
102 (20.4%)
96 (20.1%)
198 (20.3%)
0.890
Cerebral
30 (21.0%)
25 (24.0)
55 (22.3%)
0.568
Histology tumor type
0.800
Clear cell carcinoma
285 (89.3%)
299 (88.7%)
584 (89.0%)
Other
34 (10.7%)
38 (11.3%)
72 (11.0%)
Nephrectomy
246 (49.3%)
272 (56.9%)
518 (53.0%)
0.017
Hemoglobin < LLN
193 (60.5%)
207 (60.5%)
400 (60.5%)
0.995
CRP > ULN
211 (82.1%)
216 (74.7%)
427 (78.2%)
0.038
Histological diagnosis was missing for 318 patients: T stage for 78, hemoglobin for 313, CRP for 428, and ECOG status for 95 patients. The percentages in the second column were calculated only for the group of patients for whom data on these variables were available. Abbreviations: IQR = interquartile range; LLN = lower limit of normal; ULN = upper limit of normal.
