The Mechanosensory Role of Primary Cilia in Vascular Hypertension

Table 3

Pathogenesis of hypertension in PKD.

Theories	Descriptions
Inherent cardiovascular dysfunction (Figure 2)	(i) Ciliopathy; (ii) Endothelial dysfunction; (iii) Nitric oxide synthase dysfunction; (iv) Increased sympathetic nerve activity
Secondary to renal cystic formation (Figure 3)	(i) Compression of renal vasculature releases renin; (ii) Renin converts angiotensinogen to angiotensin; (iii) Activation of angiotensin receptor will induce:
	(1) Vasoconstriction
	(2) Sensitivity to catecholamines
	(3) Salt retention, and so forth.