Bradykinin Type-2 Receptor Expression Correlates with Age and Is Subjected to Transcriptional Regulation

Table 2

Genotypic and allelic frequencies of two BK-2R gene polymorphisms in normal and failing human hearts. The genotypic and allelic frequencies for two common BK-2R gene polymorphisms were calculated in both normal and failing human hearts.

(a)

Polymorphism	Genotype	Normal	IDC	CHD
−58T/C	T/T	17.0%	14.0%	17.0%
	T/C	50.0%	15.0%	50.0%
	C/C	33.0%	71.0%	33.0%
−9/+9	−9/−9	17.0%	29.0%	100%
	−9/+9	50.0%	71.0%	0%
	+9/+9	33.0%	0%	0%

(b)

Polymorphism	Allele	Frequency
		Normal	IDC	CHD	Average
−58T/C	C-allele	0.58	0.81	0.58	0.66
	T-allele	0.42	0.19	0.42	0.34
−9/+9	−9-allele	0.42	0.64	1.00	0.69
	+9-allele	0.58	0.36	0.00	0.31