Review Article

Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution

Figure 3

Pathogenesis of CVD in HIV-infected patients. HIV infection itself has been associated with subclinical atherosclerosis due to a low-grade inflammatory response leading to endothelial dysfunction. CART may promote atherosclerosis through its effects on body fat distribution, lipid metabolism and insulin sensitivity. Presumably, both HIV infection and CART promote atherosclerosis, either directly or indirectly via metabolic risk factors.
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