Phospholipase A2 Mediates Apolipoprotein-Independent Uptake of Chylomicron Remnant-Like Particles by Human Macrophages
Figure 2
Effect of plasma treatment of CRLP on macrophage lipid accumulation induced by CRLP. HMDM were incubated for 24 h in serum-free medium without the addition of CRLP (control) or with 80 μg cholesterol/mL of either CRLP+ (contains apoE) or CRLPw/o (lacks apoE). (a) Cellular TG; (b) total cholesterol (TCH) content was determined by fluorimetric assay (mean ± SD, n = 6). Results are expressed as increase of lipid content with respect to the control. *P < 0.05, **P < 0.001 versus control; #P < 0.05 versus CRLP+.
