Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit
Figure 5
Analysis of the aortic lumen by high-resolution ultrasound (HRUS). HRUS was used to measure the cross-sectional area of the thoracic and renal regions of the aortas in 3–5 animals from each animal group. (a) shows quantification of the cross-sectional area for the thoracic region of the aorta. Note that the hSTAT3-treated, the hIL-10-treated, and the hSTAT3-plus-hIL-10-treated animals all had a much larger cross sectional area than the AAV/Neo-treated animals, indicating significant efficacy. Similarly in (b), quantification of the data for the renal region of the aorta shows a much larger lumen size for the hSTAT3-, hIL-10-, and hSTAT3-plus-hIL-10-treated animals compared to AAV/Neo-treated animals.
