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International Journal of Vascular Medicine
Volume 2012 (2012), Article ID 543218, 17 pages
http://dx.doi.org/10.1155/2012/543218
Review Article

Blood Flow Restricted Exercise and Vascular Function

1Department of Physiology, Yamanashi Institute of Environmental Sciences, Kami-yoshida 5597, Fuji-yoshida, Yamanashi 4030005, Japan
2Northern Regions, Life long Sports Research Center, Hokusho University, Bunkyoudai 23, Ebetsu, Hokkaido 0698511, Japan
3Department of Sports Education, Hokusho University, Bunkyodai 23, Ebetsu, Hokkaido 0698511, Japan

Received 15 June 2012; Revised 3 August 2012; Accepted 6 August 2012

Academic Editor: Beth Parker

Copyright © 2012 Masahiro Horiuchi and Koichi Okita. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Osler, The Principles and Practice of Medicine, D. Appletion and Company, New York, NY, USA, 1892.
  2. J. Blacher, A. P. Guerin, B. Pannier, S. J. Marchais, M. E. Safar, and G. M. London, “Impact of aortic stiffness on survival in end-stage renal disease,” Circulation, vol. 99, no. 18, pp. 2434–2439, 1999. View at Scopus
  3. E. G. Lakatta, “Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons,” Heart Failure Reviews, vol. 7, no. 1, pp. 29–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Laurent, P. Boutouyrie, R. Asmar et al., “Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients,” Hypertension, vol. 37, no. 5, pp. 1236–1241, 2001. View at Scopus
  5. J. Sattelmair, J. Pertman, E. L. Ding, H. W. Kohl III, W. Haskell, and I. M. Lee, “Dose response between physical activity and risk of coronary heart disease: a meta-analysis,” Circulation, vol. 124, no. 7, pp. 789–795, 2011. View at Publisher · View at Google Scholar
  6. H. D. Sesso, R. S. Paffenbarger, and I. M. Lee, “Physical activity and coronary heart disease in men: the Harvard Alumni Health Study,” Circulation, vol. 102, no. 9, pp. 975–980, 2000. View at Scopus
  7. I. M. Lee and R. S. Paffenbarger Jr., “Physical activity and stroke incidence: the Harvard Alumni Health Study,” Stroke, vol. 29, no. 10, pp. 2049–2054, 1998. View at Scopus
  8. G. C. W. Wendel-Vos, A. J. Schuit, E. J. M. Feskens et al., “Physical activity and stroke. A meta-analysis of observational data,” International Journal of Epidemiology, vol. 33, no. 4, pp. 787–798, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Sharon Plowman and L. Denise Smith, Exercise Physiology for Health, Fitness, and Performance, Lippincott Williams & Wilkins, 2007.
  10. American College of Sports Medicine, ACSM’S Guideline for Exercise Testing and Prescription, Lippincott Williams & Wilkins, 7th edition, 2006.
  11. H. Tanaka, F. A. Dinenno, K. D. Monahan, C. M. Clevenger, C. A. DeSouza, and D. R. Seals, “Aging, habitual exercise, and dynamic arterial compliance,” Circulation, vol. 102, no. 11, pp. 1270–1275, 2000. View at Scopus
  12. F. A. Dinenno, D. R. Seals, C. A. Desouza, and H. Tanaka, “Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects,” Journal of Physiology, vol. 531, no. 2, pp. 573–579, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. M. A. Williams, W. L. Haskell, P. A. Ades et al., “Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism,” Circulation, vol. 116, no. 5, pp. 572–584, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. American College of Sports Medicine, “Position stand: progression models in resistance training for healthy adults,” Medicine and Science in Sports and Exercise, vol. 41, no. 3, pp. 687–708, 2009.
  15. M. Miyachi, H. Kawano, J. Sugawara et al., “Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study,” Circulation, vol. 110, no. 18, pp. 2858–2863, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. S. M. Roth, G. F. Martel, F. M. Ivey et al., “High-volume, heavy-resistance strength training and muscle damage in young and older women,” Journal of Applied Physiology, vol. 88, no. 3, pp. 1112–1118, 2000. View at Scopus
  17. T. Abe, T. Yasuda, T. Midorikawa et al., “Skeletal muscle size and circulating IGF-1 are increased after two weeks of twice daily "KAATSU" resistance training,” International Journal of KAATSU Training Research, vol. 1, no. 1, pp. 6–12, 2005. View at Publisher · View at Google Scholar
  18. H. Madarame, M. Neya, E. Ochi, K. Nakazato, Y. Sato, and N. Ishii, “Cross-transfer effects of resistance training with blood flow restriction,” Medicine and Science in Sports and Exercise, vol. 40, no. 2, pp. 258–263, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. D. R. Moore, K. A. Burgomaster, L. M. Schofield, M. J. Gibala, D. G. Sale, and S. M. Phillips, “Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion,” European Journal of Applied Physiology, vol. 92, no. 4-5, pp. 399–406, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Shinohara, M. Kouzaki, T. Yoshihisa, and T. Fukunaga, “Efficacy of tourniquet ischemia for strength training with low resistance,” European Journal of Applied Physiology and Occupational Physiology, vol. 77, no. 1-2, pp. 189–191, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Takarada, Y. Sato, and N. Ishii, “Effects of resistance exercise combined with vascular occlusion on muscle function in athletes,” European Journal of Applied Physiology, vol. 86, no. 4, pp. 308–314, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Takarada, H. Takazawa, Y. Sato, S. Takebayashi, Y. Tanaka, and N. Ishii, “Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans,” Journal of Applied Physiology, vol. 88, no. 6, pp. 2097–2106, 2000. View at Scopus
  23. Y. Takarada, T. Tsuruta, and N. Ishii, “Cooperative effects of exercise and occlusive stimuli on muscular function in low-intensity resistance exercise with moderate vascular occlusion,” Japanese Journal of Physiology, vol. 54, no. 6, pp. 585–592, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Abe, C. F. Kearns, and Y. Sato, “Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training,” Journal of Applied Physiology, vol. 100, no. 5, pp. 1460–1466, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Van Merode, P. J. J. Hick, A. P. G. Hoeks, K. H. Rahn, and R. S. Reneman, “Carotid artery wall properties in normotensive and borderline hypertensive subjects of various ages,” Ultrasound in Medicine and Biology, vol. 14, no. 7, pp. 563–569, 1988. View at Scopus
  26. T. Hirai, S. Sasayama, T. Kawasaki, and S. I. Yagi, “Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis,” Circulation, vol. 80, no. 1, pp. 78–86, 1989. View at Scopus
  27. D. K. Arnett, G. W. Evans, and W. A. Riley, “Arterial stiffness: a new cardiovascular risk factor?” American Journal of Epidemiology, vol. 140, no. 8, pp. 669–682, 1994. View at Scopus
  28. H. Tanaka, C. A. DeSouza, and D. R. Seals, “Absence of age-related increase in central arterial stiffness in physically active women,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 1, pp. 127–132, 1998. View at Scopus
  29. A. P. Avolio, D. Fa-Quan, and L. Wei-Qiang, “Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China,” Circulation, vol. 71, no. 2, pp. 202–210, 1985. View at Scopus
  30. A. M. Dart and B. A. Kingwell, “Pulse pressure—a review of mechanisms and clinical relevance,” Journal of the American College of Cardiology, vol. 37, no. 4, pp. 975–984, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. R. J. Hodes, E. G. Lakatta, and C. T. McNeil, “Another modifiable risk factor for cardiovascular disease? Some evidence points to arterial stiffness,” Journal of the American Geriatrics Society, vol. 43, no. 5, pp. 581–582, 1995. View at Scopus
  32. J. Blacher, R. Asmar, S. Djane, G. M. London, and M. E. Safar, “Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients,” Hypertension, vol. 33, no. 5, pp. 1111–1117, 1999. View at Scopus
  33. E. G. Lakatta, “Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons,” Heart Failure Reviews, vol. 7, no. 1, pp. 29–49, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. F. U. S. Mattace-Raso, T. J. M. Van Der Cammen, A. Hofman et al., “Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study,” Circulation, vol. 113, no. 5, pp. 657–663, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Sutton-Tyrrell, S. S. Najjar, R. M. Boudreau et al., “Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults,” Circulation, vol. 111, no. 25, pp. 3384–3390, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. T. W. Hansen, J. A. Staessen, C. Torp-Pedersen et al., “Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population,” Circulation, vol. 113, no. 5, pp. 664–670, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. S. T. Yao, J. T. Hobbs, and W. T. Irvine, “Ankle systolic pressure measurements in arterial disease affecting the lower extremities,” British Journal of Surgery, vol. 56, no. 9, pp. 676–679, 1969. View at Scopus
  38. P. Greenland, J. Abrams, G. P. Aurigemma et al., “Prevention Conference V: beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III,” Circulation, vol. 101, no. 1, pp. E16–E22, 2000. View at Scopus
  39. K. Ouriel, A. E. McDonnell, C. E. Metz, and C. K. Zarins, “A critical evaluation of stress testing in the diagnosis of peripheral vascular disease,” Surgery, vol. 91, no. 6, pp. 686–693, 1982. View at Scopus
  40. Y. Koji, H. Tomiyama, H. Ichihashi et al., “Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease,” American Journal of Cardiology, vol. 94, no. 7, pp. 868–872, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. E. Safar and G. M. London, “Therapeutic studies and arterial stiffness in hypertension: recommendations of the European Society of Hypertension,” Journal of Hypertension, vol. 18, no. 11, pp. 1527–1535, 2000. View at Scopus
  42. S. Laurent, J. Cockcroft, L. Van Bortel et al., “Expert consensus document on arterial stiffness: methodological issues and clinical applications,” European Heart Journal, vol. 27, no. 21, pp. 2588–2605, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Asmar, “Pulse wave velocity: principle and measurement,” in Arterial Stiffness and Pulse Wave Velocity: Clinical Application, R. Asmar, Ed., pp. 25–26, Elsevier, Amsterdam, The Netherlands, 1999.
  44. A. P. Guerin, J. Blacher, B. Pannier, S. J. Marchais, M. E. Safar, and G. M. London, “Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure,” Circulation, vol. 103, no. 7, pp. 987–992, 2001. View at Scopus
  45. S. Laurent, P. Boutouyrie, R. Asmar et al., “Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients,” Hypertension, vol. 37, no. 5, pp. 1236–1241, 2001. View at Scopus
  46. S. Meaume, A. Benetos, O. F. Henry, A. Rudnichi, and M. E. Safar, “Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 12, pp. 2046–2050, 2001. View at Scopus
  47. J. E. Deanfield, J. P. Halcox, and T. J. Rabelink, “Endothelial function and dysfunction: testing and clinical relevance,” Circulation, vol. 115, no. 10, pp. 1285–1295, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Deanfield, A. Donald, C. Ferri et al., “Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the working group on endothelin and endothelial factors of the European society of hypertension,” Journal of Hypertension, vol. 23, no. 1, pp. 7–17, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. K. E. Pyke and M. E. Tschakovsky, “The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function,” Journal of Physiology, vol. 568, no. 2, pp. 357–369, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. D. H. J. Thijssen, M. A. Black, K. E. Pyke et al., “Assessment of flow-mediated dilation in humans: a methodological and physiological guideline,” American Journal of Physiology, vol. 300, no. 1, pp. H2–H12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. N. Gokce, J. F. Keaney, L. M. Hunter, M. T. Watkins, J. O. Menzoian, and J. A. Vita, “Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study,” Circulation, vol. 105, no. 13, pp. 1567–1572, 2002. View at Publisher · View at Google Scholar · View at Scopus
  52. N. Gokce, J. F. Keaney, L. M. Hunter et al., “Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease,” Journal of the American College of Cardiology, vol. 41, no. 10, pp. 1769–1775, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. M. E. Widlansky, N. Gokce, J. F. Keaney, and J. A. Vita, “The clinical implications of endothelial dysfunction,” Journal of the American College of Cardiology, vol. 42, no. 7, pp. 1149–1160, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. L. A. Talbot, C. H. Morrell, E. J. Metter, and J. L. Fleg, “Comparison of cardiorespiratory fitness versus leisure time physical activity as predictors of coronary events in men aged < or = 65 years and >65 years,” American Journal of Cardiology, vol. 89, no. 10, pp. 1187–1192, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. P. T. Williams, “Physical fitness and activity as separate heart disease risk factors: a meta-analysis,” Medicine and Science in Sports and Exercise, vol. 33, no. 5, pp. 754–761, 2001. View at Scopus
  56. P. V. Vaitkevicius, J. L. Fleg, J. H. Engel et al., “Effects of age and aerobic capacity on arterial stiffness in healthy adults,” Circulation, vol. 88, no. 4, pp. 1456–1462, 1993. View at Scopus
  57. A. Schmidt-Trucksass, A. Schmid, C. Brunner et al., “Arterial properties of the carotid and femoral artery in endurance-trained and paraplegic subjects,” Journal of Applied Physiology, vol. 89, no. 5, pp. 1956–1963, 2000. View at Scopus
  58. T. Otsuki, S. Maeda, M. Iemitsu et al., “Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men,” American Journal of Physiology, vol. 292, no. 2, pp. H786–H791, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Otsuki, S. Maeda, M. Iemitsu et al., “Relationship between arterial stiffness and athletic training programs in young adult men,” American Journal of Hypertension, vol. 20, no. 9, pp. 967–973, 2007. View at Publisher · View at Google Scholar · View at Scopus
  60. B. A. Kingwell, J. D. Cameron, K. J. Gillies, G. L. Jennings, and A. M. Dart, “Arterial compliance may influence baroreflex function in athletes and hypertensives,” American Journal of Physiology, vol. 268, no. 1, pp. H411–H418, 1995. View at Scopus
  61. T. Kakiyama, J. Sugawara, H. Murakami, S. Maeda, S. Kuno, and M. Matsuda, “Effects of short-term endurance training on aortic distensibility in young males,” Medicine and Science in Sports and Exercise, vol. 37, no. 2, pp. 267–271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. M. Yoshizawa, S. Maeda, A. Miyaki et al., “Additive beneficial effects of lactotripeptides intake with regular exercise on endothelium-dependent dilatation in postmenopausal women,” American Journal of Hypertension, vol. 23, no. 4, pp. 368–372, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. J. D. Cameron and A. M. Dart, “Exercise training increases total systemic arterial compliance in humans,” American Journal of Physiology, vol. 266, no. 2, pp. H693–H701, 1994. View at Scopus
  64. J. Sugawara, K. Hayashi, T. Yokoi et al., “Brachial-ankle pulse wave velocity: an index of central arterial stiffness?” Journal of Human Hypertension, vol. 19, no. 5, pp. 401–406, 2005. View at Publisher · View at Google Scholar · View at Scopus
  65. S. R. Collier, J. A. Kanaley, R. Carhart et al., “Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre- and stage-1 hypertensives,” Journal of Human Hypertension, vol. 22, no. 10, pp. 678–686, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. Y. Higashi, S. Sasaki, S. Kurisu et al., “Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide,” Circulation, vol. 100, no. 11, pp. 1194–1202, 1999. View at Scopus
  67. C. Goto, K. Nishioka, T. Umemura et al., “Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans,” American Journal of Hypertension, vol. 20, no. 8, pp. 825–830, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. E. De Filippis, K. Cusi, G. Ocampo et al., “Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 12, pp. 4903–4910, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. R. Hambrecht, A. Wolf, S. Gielen et al., “Effect of exercise on coronary endothelial function in patients with coronary artery disease,” New England Journal of Medicine, vol. 342, no. 7, pp. 454–460, 2000. View at Publisher · View at Google Scholar · View at Scopus
  70. A. W. Gardner, D. J. Sieminski, and P. S. Montgomery, “Physical activity is related to ankle/brachial index in subjects without peripheral arterial occlusive disease,” Angiology, vol. 48, no. 10, pp. 883–891, 1997. View at Scopus
  71. S. B. Feinstein, P. Voci, and F. Pizzuto, “Noninvasive surrogate markers of atherosclerosis,” American Journal of Cardiology, vol. 89, no. 5, pp. 31C–43C, 2002. View at Scopus
  72. K. H. Schmitz, D. K. Arnett, A. Bank et al., “Arterial distensibility and physical activity in the ARIC study,” Medicine and Science in Sports and Exercise, vol. 33, no. 12, pp. 2065–2071, 2001. View at Scopus
  73. A. Schmidt-Trucksäss, D. Grathwohl, I. Frey et al., “Relation of leisure-time physical activity to structural and functional arterial properties of the common carotid artery in male subjects,” Atherosclerosis, vol. 145, no. 1, pp. 107–114, 1999. View at Publisher · View at Google Scholar · View at Scopus
  74. C. Vlachopoulos, D. Kardara, A. Anastasakis et al., “Arterial stiffness and wave reflections in marathon runners,” American Journal of Hypertension, vol. 23, no. 9, pp. 974–979, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. J. D. MacDougall, D. Tuxen, and D. G. Sale, “Arterial blood pressure response to heavy resistance exercise,” Journal of Applied Physiology, vol. 58, no. 3, pp. 785–790, 1985. View at Scopus
  76. J. S. Petrofsky and A. R. Lind, “Aging, isometric strength and endurance, and cardiovascular responses to static effort,” Journal of Applied Physiology, vol. 38, no. 1, pp. 91–95, 1975. View at Scopus
  77. T. Ogawa, R. J. Spina, W. H. Martin et al., “Effects of aging, sex, and physical training on cardiovascular responses to exercise,” Circulation, vol. 86, no. 2, pp. 494–503, 1992. View at Scopus
  78. J. R. Stratton, W. C. Levy, M. D. Cerqueira, R. S. Schwartz, and I. B. Abrass, “Cardiovascular responses to exercise: effects of aging and exercise training in healthy men,” Circulation, vol. 89, no. 4, pp. 1648–1655, 1994. View at Scopus
  79. D. A. Bertovic, T. K. Waddell, C. D. Gatzka, J. D. Cameron, A. M. Dart, and B. A. Kingwell, “Muscular strength training is associated with low arterial compliance and high pulse pressure,” Hypertension, vol. 33, no. 6, pp. 1385–1391, 1999. View at Scopus
  80. H. Kawano, M. Tanimoto, K. Yamamoto et al., “Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test,” Experimental Physiology, vol. 93, no. 2, pp. 296–302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  81. M. Miyachi, A. J. Donato, K. Yamamoto et al., “Greater age-related reductions in central arterial compliance in resistance-trained men,” Hypertension, vol. 41, no. 1, pp. 130–135, 2003. View at Publisher · View at Google Scholar · View at Scopus
  82. K. S. Heffernan, S. Y. Jae, G. H. Echols, N. R. Lepine, and B. Fernhall, “Arterial stiffness and wave reflection following exercise in resistance-trained men,” Medicine and Science in Sports and Exercise, vol. 39, no. 5, pp. 842–848, 2007. View at Publisher · View at Google Scholar · View at Scopus
  83. A. E. DeVan, D. Umpierre, H. F. Lin et al., “Habitual resistance exercise and endothelial ischemia-reperfusion injury in young adults,” Atherosclerosis, vol. 219, no. 1, pp. 191–193, 2011. View at Publisher · View at Google Scholar
  84. S. A. Phillips, E. Das, J. Wang, K. Pritchard, and D. D. Gutterman, “Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion,” Journal of Applied Physiology, vol. 110, no. 4, pp. 1013–1020, 2011. View at Publisher · View at Google Scholar · View at Scopus
  85. C. A. Fahs, K. S. Heffernan, S. Ranadive, S. Y. Jae, and B. Fernhall, “Muscular strength is inversely associated with aortic stiffness in young men,” Medicine and Science in Sports and Exercise, vol. 42, no. 9, pp. 1619–1624, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. M. Rakobowchuk, C. L. McGowan, P. C. De Groot et al., “Effect of whole body resistance training on arterial compliance in young men,” Experimental Physiology, vol. 90, no. 4, pp. 645–651, 2005. View at Publisher · View at Google Scholar · View at Scopus
  87. A. S. Fjeldstad, M. G. Bemben, and D. A. Bemben, “Resistance training effects on arterial compliance in premenopausal women,” Angiology, vol. 60, no. 6, pp. 750–756, 2009. View at Scopus
  88. F. Poelkens, M. Rakobowchuk, K. A. Burgomaster, M. T. E. Hopman, S. M. Phillips, and M. J. MacDonald, “Effect of unilateral resistance training on arterial compliance in elderly men,” Applied Physiology, Nutrition and Metabolism, vol. 32, no. 4, pp. 670–676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  89. J. D. Kingsley, V. Mcmillan, and A. Figueroa, “Resistance exercise training does not affect postexercise hypotension and wave reflection in women with fibromyalgia,” Applied Physiology, Nutrition and Metabolism, vol. 36, no. 2, pp. 254–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. D. P. Casey, D. T. Beck, and R. W. Braith, “Progressive resistance training without volume increases does not alter arterial stiffness and aortic wave reflection,” Experimental Biology and Medicine, vol. 232, no. 9, pp. 1228–1235, 2007. View at Publisher · View at Google Scholar · View at Scopus
  91. D. P. Casey, G. L. Pierce, K. S. Howe, M. C. Mering, and R. W. Braith, “Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women,” European Journal of Applied Physiology, vol. 100, no. 4, pp. 403–408, 2007. View at Publisher · View at Google Scholar · View at Scopus
  92. M. Rakobowchuk, C. L. McGowan, P. C. De Groot, J. W. Hartman, S. M. Phillips, and M. J. MacDonald, “Endothelial function of young healthy males following whole body resistance training,” Journal of Applied Physiology, vol. 98, no. 6, pp. 2185–2190, 2005. View at Publisher · View at Google Scholar · View at Scopus
  93. M. M. Anton, M. Y. Cortez-Cooper, A. E. DeVan, D. B. Neidre, J. N. Cook, and H. Tanaka, “Resistance training increases basal limb blood flow and vascular conductance in aging humans,” Journal of Applied Physiology, vol. 101, no. 5, pp. 1351–1355, 2006. View at Publisher · View at Google Scholar · View at Scopus
  94. M. Tanimoto, H. Kawano, Y. Gando et al., “Low-intensity resistance training with slow movement and tonic force generation increases basal limb blood flow,” Clinical Physiology and Functional Imaging, vol. 29, no. 2, pp. 128–135, 2009. View at Publisher · View at Google Scholar · View at Scopus
  95. S. R. Copeland, M. C. Mills, J. L. Lerner, M. F. Crizer, C. W. Thompson, and J. M. Sullivan, “Hemodynamic effects of aerobic vs resistance exercise,” Journal of Human Hypertension, vol. 10, no. 11, pp. 747–753, 1996. View at Scopus
  96. J. D. Kingsley and A. Figueroa, “Effects of resistance exercise training on resting and post-exercise forearm blood flow and wave reflection in overweight and obese women,” Journal of Human Hypertension, vol. 26, no. 11, pp. 684–690, 2012. View at Publisher · View at Google Scholar
  97. A. D. Williams, K. D. Ahuja, J. B. Almond, I. K. Robertson, and M. J. Ball, “Progressive resistance training might improve vascular function in older women but not in older men,” Journal of Science and Medicine in Sport. In press.
  98. K. S. Heffernan, C. A. Fahs, G. A. Iwamoto et al., “Resistance exercise training reduces central blood pressure and improves microvascular function in African American and white men,” Atherosclerosis, vol. 207, no. 1, pp. 220–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. M. Vona, G. M. Codeluppi, T. Iannino, E. Ferrari, J. Bogousslavsky, and L. K. Von Segesser, “Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction,” Circulation, vol. 119, no. 12, pp. 1601–1608, 2009. View at Publisher · View at Google Scholar · View at Scopus
  100. H. Kawano, H. Tanaka, and M. Miyachi, “Resistance training and arterial compliance: keeping the benefits while minimizing the stiffening,” Journal of Hypertension, vol. 24, no. 9, pp. 1753–1759, 2006. View at Publisher · View at Google Scholar · View at Scopus
  101. A. Figueroa, S. Y. Park, D. Y. Seo, M. A. Sanchez-Gonzalez, and Y. H. Baek, “Combined resistance and endurance exercise training improves arterial stiffness, blood pressure, and muscle strength in postmenopausal women,” Menopause, vol. 18, no. 9, pp. 981–984, 2011. View at Publisher · View at Google Scholar · View at Scopus
  102. S. Maeda, T. Otsuki, M. Iemitsu et al., “Effects of leg resistance training on arterial function in older men,” British Journal of Sports Medicine, vol. 40, no. 10, pp. 867–869, 2006. View at Publisher · View at Google Scholar · View at Scopus
  103. M. Y. Cortez-Cooper, M. M. Anton, A. E. DeVan, D. B. Neidre, J. N. Cook, and H. Tanaka, “The effects of strength training on central arterial compliance in middle-aged and older adults,” European Journal of Cardiovascular Prevention and Rehabilitation, vol. 15, no. 2, pp. 149–155, 2008. View at Publisher · View at Google Scholar · View at Scopus
  104. M. Yoshizawa, S. Maeda, A. Miyaki et al., “Effect of 12 weeks of moderate-intensity resistance training on arterial stiffness: a randomised controlled trial in women aged 32–59 years,” British Journal of Sports Medicine, vol. 43, no. 8, pp. 615–618, 2009. View at Publisher · View at Google Scholar · View at Scopus
  105. T. P. Olson, D. R. Dengel, A. S. Leon, and K. H. Schmitz, “Moderate resistance training and vascular health in overweight women,” Medicine and Science in Sports and Exercise, vol. 38, no. 9, pp. 1558–1564, 2006. View at Publisher · View at Google Scholar · View at Scopus
  106. T. Okamoto, M. Masuhara, and K. Ikuta, “Effect of low-intensity resistance training on arterial function,” European Journal of Applied Physiology, vol. 111, no. 5, pp. 743–748, 2011. View at Publisher · View at Google Scholar · View at Scopus
  107. A. S. Dean, J. R. Libonati, D. Madonna, S. J. Ratcliffe, and K. B. Margulies, “Resistance training improves vasoreactivity in end-stage heart failure patients on inotropic support,” Journal of Cardiovascular Nursing, vol. 26, no. 3, pp. 218–223, 2011. View at Publisher · View at Google Scholar · View at Scopus
  108. R. Pratley, B. Nicklas, M. Rubin et al., “Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men,” Journal of Applied Physiology, vol. 76, no. 1, pp. 133–137, 1994. View at Scopus
  109. T. Raastad, T. Glomsheller, T. Bjøro, and J. Hallén, “Changes in human skeletal muscle contractility and hormone status during 2 weeks of heavy strength training,” European Journal of Applied Physiology, vol. 84, no. 1-2, pp. 54–63, 2001. View at Publisher · View at Google Scholar · View at Scopus
  110. M. Failla, A. Grappiolo, G. Emanuelli et al., “Sympathetic tone restrains arterial distensibility of healthy and atherosclerotic subjects,” Journal of Hypertension, vol. 17, no. 8, pp. 1117–1123, 1999. View at Publisher · View at Google Scholar · View at Scopus
  111. T. Okamoto, M. Masuhara, and K. Ikuta, “Upper but not lower limb resistance training increases arterial stiffness in humans,” European Journal of Applied Physiology, vol. 107, no. 2, pp. 127–134, 2009. View at Publisher · View at Google Scholar · View at Scopus
  112. D. R. Seals and R. G. Victor, “Regulation of muscle sympathetic nerve activity during exercise in humans,” Exercise and Sport Sciences Reviews, vol. 19, pp. 313–349, 1991. View at Scopus
  113. S. Fujita, T. Abe, M. J. Drummond et al., “Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis,” Journal of Applied Physiology, vol. 103, no. 3, pp. 903–910, 2007. View at Publisher · View at Google Scholar · View at Scopus
  114. T. M. Manini and B. C. Clark, “Blood flow restricted exercise and skeletal muscle health,” Exercise and Sport Sciences Reviews, vol. 37, no. 2, pp. 78–85, 2009. View at Publisher · View at Google Scholar · View at Scopus
  115. J. R. Pierce, B. C. Clark, L. L. Ploutz-Snyder, and J. A. Kanaley, “Growth hormone and muscle function responses to skeletal muscle ischemia,” Journal of Applied Physiology, vol. 101, no. 6, pp. 1588–1595, 2006. View at Publisher · View at Google Scholar · View at Scopus
  116. H. Takano, T. Morita, H. Iida et al., “Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow,” European Journal of Applied Physiology, vol. 95, no. 1, pp. 65–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  117. Y. Takarada, Y. Nakamura, S. Aruga, T. Onda, S. Miyazaki, and N. Ishii, “Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion,” Journal of Applied Physiology, vol. 88, no. 1, pp. 61–65, 2000. View at Scopus
  118. T. Suga, K. Okita, N. Morita et al., “Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction,” Journal of Applied Physiology, vol. 106, no. 4, pp. 1119–1124, 2009. View at Publisher · View at Google Scholar · View at Scopus
  119. S. D. Patterson and R. A. Ferguson, “Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women,” European Journal of Applied Physiology, vol. 108, no. 5, pp. 1025–1033, 2010. View at Publisher · View at Google Scholar · View at Scopus
  120. C. S. Fry, E. L. Glynn, M. J. Drummond et al., “Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men,” Journal of Applied Physiology, vol. 108, no. 5, pp. 1199–1209, 2010. View at Publisher · View at Google Scholar · View at Scopus
  121. D. M. Gundermann, C. S. Fry, J. M. Dickinson et al., “Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise,” Journal of Applied Physiology, vol. 112, no. 9, pp. 1520–1528, 2012. View at Publisher · View at Google Scholar
  122. S. Takada, K. Okita, T. Suga et al., “Low-intensity exercise can increase muscle mass and strength proportionally to enhanced metabolic stress under ischemic conditions,” Journal of Applied Physiology, vol. 113, no. 2, pp. 199–205, 2012. View at Publisher · View at Google Scholar
  123. L. H. Naylor, C. J. Weisbrod, G. O'Driscoll, and D. J. Green, “Measuring peripheral resistance and conduit arterial structure in humans using Doppler ultrasound,” Journal of Applied Physiology, vol. 98, no. 6, pp. 2311–2315, 2005. View at Publisher · View at Google Scholar · View at Scopus
  124. C. A. Fahs, L. M. Rossow, D. I. Seo et al., “Effect of different types of resistance exercise on arterial compliance and calf blood flow,” European Journal of Applied Physiology, vol. 111, no. 12, pp. 2969–2975, 2011. View at Publisher · View at Google Scholar · View at Scopus
  125. I. B. Wilkinson, A. Qasem, C. M. McEniery, D. J. Webb, A. P. Avolio, and J. R. Cockcroft, “Nitric oxide regulates local arterial distensibility in vivo,” Circulation, vol. 105, no. 2, pp. 213–217, 2002. View at Publisher · View at Google Scholar · View at Scopus
  126. P. Boutouyrie, P. Lacolley, X. Girerd, L. Beck, M. Safar, and S. Laurent, “Sympathetic activation decreases medium-sized arterial compliance in humans,” American Journal of Physiology, vol. 267, no. 4, pp. H1368–H1376, 1994. View at Scopus
  127. S. J. Kim, V. D. Sherk, M. G. Bemben, and D. A. Bemben, “Effects of short-term, low-intensity resistance training with vascular restriction on arterial compliance in untrained young men,” International Journal of KAATSU Training Research, vol. 5, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar
  128. B. C. Clark, T. M. Manini, R. L. Hoffman et al., “Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults,” Scandinavia Journal of Medicine and Science in Sports, vol. 21, no. 5, pp. 653–662, 2011. View at Publisher · View at Google Scholar
  129. C. A. Fahs, L. M. Rossow, J. P. Loenneke et al., “Effect of different types of lower body resistance training on arterial compliance and calf blood flow,” Clinical Physiology and Functional Imaging, vol. 32, no. 1, pp. 45–51, 2012. View at Publisher · View at Google Scholar
  130. H. Ozaki, T. Yasuda, R. Ogasawara, M. Sakamaki-Sunaga, H. Naito, and T. Abe, “Effects of high-intensity and blood flow-restricted low-intensity resistance training on carotid arterial compliance: role of blood pressure during training sessions,” European Journal of Applied Physiology. In press.
  131. L. M. Rossow, C. A. Fahs, V. D. Sherk, D. I. Seo, D. A. Bemben, and M. G. Bemben, “The effect of acute blood-flow-restricted resistance exercise on postexercise blood pressure,” Clinical Physiology and Functional Imaging, vol. 31, no. 6, pp. 429–434, 2011. View at Publisher · View at Google Scholar · View at Scopus
  132. M. J. Kenney and D. R. Scals, “Postexercise hypotension: key features, mechanisms, and clinical significance,” Hypertension, vol. 22, no. 5, pp. 653–664, 1993. View at Scopus
  133. J. R. Halliwill, “Mechanisms and clinical implications of post-exercise hypotension in humans,” Exercise and Sport Sciences Reviews, vol. 29, no. 2, pp. 65–70, 2001. View at Scopus
  134. H. Ozaki, M. Miyachi, T. Nakajima, and T. Abe, “Effects of 10 weeks walk training with leg blood flow reduction on carotid arterial compliance and muscle size in the elderly adults,” Angiology, vol. 62, no. 1, pp. 81–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  135. B. A. Parker, M. J. Kalasky, and D. N. Proctor, “Evidence for sex differences in cardiovascular aging and adaptive responses to physical activity,” European Journal of Applied Physiology, vol. 110, no. 2, pp. 235–246, 2010. View at Publisher · View at Google Scholar · View at Scopus
  136. K. L. Moreau, A. J. Donato, D. R. Seals, C. A. DeSouza, and H. Tanaka, “Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women,” Cardiovascular Research, vol. 57, no. 3, pp. 861–868, 2003. View at Publisher · View at Google Scholar · View at Scopus
  137. T. Abe, M. Sakamaki, S. Fujita et al., “Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults,” Journal of Geriatric Physical Therapy, vol. 33, no. 1, pp. 34–40, 2010. View at Scopus
  138. C. Evans, S. Vance, and M. Brown, “Short-term resistance training with blood flow restriction enhances microvascular filtration capacity of human calf muscles,” Journal of Sports Sciences, vol. 28, no. 9, pp. 999–1007, 2010. View at Publisher · View at Google Scholar · View at Scopus
  139. C. P. Renzi, H. Tanaka, and J. Sugawara, “Effects of leg blood flow restriction during walking on cardiovascular function,” Medicine and Science in Sports and Exercise, vol. 42, no. 4, pp. 726–732, 2010. View at Publisher · View at Google Scholar · View at Scopus
  140. D. P. Credeur, B. C. Hollis, and M. A. Welsch, “Effects of handgrip training with venous restriction on brachial artery vasodilation,” Medicine and Science in Sports and Exercise, vol. 42, no. 7, pp. 1296–1302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  141. J. E. Hunt, L. A. Walton, and R. A. Ferguson, “Brachial artery modifications to blood flow-restricted handgrip training and detraining,” Journal of Applied Physiology, vol. 112, no. 6, pp. 956–961, 2012. View at Publisher · View at Google Scholar
  142. U. Förstermann, “Endothelial NO synthase as a source of NO and superoxide,” European Journal of Clinical Pharmacology, vol. 62, no. 13, pp. 5–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  143. Y. Higashi, K. Noma, M. Yoshizumi, and Y. Kihara, “Endothelial function and oxidative stress in cardiovascular diseases,” Circulation Journal, vol. 73, no. 3, pp. 411–418, 2009. View at Publisher · View at Google Scholar · View at Scopus
  144. T. Heitzer, T. Schlinzig, K. Krohn, T. Meinertz, and T. Münzel, “Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease,” Circulation, vol. 104, no. 22, pp. 2673–2678, 2001. View at Scopus
  145. R. J. Bloomer, A. C. Fry, M. J. Falvo, and C. A. Moore, “Protein carbonyls are acutely elevated following single set anaerobic exercise in resistance trained men,” Journal of Science and Medicine in Sport, vol. 10, no. 6, pp. 411–417, 2007. View at Publisher · View at Google Scholar · View at Scopus
  146. R. J. Bloomer, M. J. Falvo, A. C. Fry, B. K. Schilling, W. A. Smith, and C. A. Moore, “Oxidative stress response in trained men following repeated squats or sprints,” Medicine and Science in Sports and Exercise, vol. 38, no. 8, pp. 1436–1442, 2006. View at Publisher · View at Google Scholar · View at Scopus
  147. R. J. Bloomer, A. H. Goldfarb, L. Wideman, M. J. McKenzie, and L. A. Consitt, “Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress,” Journal of Strength and Conditioning Research, vol. 19, no. 2, pp. 276–285, 2005. View at Publisher · View at Google Scholar · View at Scopus
  148. M. B. Hudson, P. A. Hosick, G. O. Mccaulley et al., “The effect of resistance exercise on humoral markers of oxidative stress,” Medicine and Science in Sports and Exercise, vol. 40, no. 3, pp. 542–548, 2008. View at Publisher · View at Google Scholar · View at Scopus
  149. J. Lee, A. H. Goldfarb, M. H. Rescino, S. Hegde, S. Patrick, and K. Apperson, “Eccentric exercise effect on blood oxidative-stress markers and delayed onset of muscle soreness,” Medicine and Science in Sports and Exercise, vol. 34, no. 3, pp. 443–448, 2002. View at Scopus
  150. S. R. McAnulty, L. S. McAnulty, D. C. Nieman, J. D. Morrow, A. C. Utter, and C. L. Dumke, “Effect of resistance exercise and carbohydrate ingestion on oxidative stress,” Free Radical Research, vol. 39, no. 11, pp. 1219–1224, 2005. View at Publisher · View at Google Scholar · View at Scopus
  151. J. M. McBride, W. J. Kraemer, T. Triplett-McBride, and W. Sebastianelli, “Effect of resistance exercise on free radical production,” Medicine and Science in Sports and Exercise, vol. 30, no. 1, pp. 67–72, 1998. View at Publisher · View at Google Scholar · View at Scopus
  152. Y. Hellsten, H. A. Hansson, L. Johnson, U. Frandsen, and B. Sjödin, “Increased expression of xanthine oxidase and insulin-like growth factor I (IGF-I) immunoreactivity in skeletal muscle after strenuous exercise in humans,” Acta Physiologica Scandinavica, vol. 157, no. 2, pp. 191–197, 1996. View at Scopus
  153. A. H. Goldfarb, R. S. Garten, P. D. M. Chee et al., “Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion,” European Journal of Applied Physiology, vol. 104, no. 5, pp. 813–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  154. P. B. Dobrin, “Mechanical factors associated with the development of intimal and medial thickening in vein grafts subjected to arterial pressure: a model of arteries exposed to hypertension,” Hypertension, vol. 26, no. 1, pp. 38–43, 1995. View at Scopus
  155. D. A. Dobrosielski, F. L. Greenway, D. A. Welsh, S. M. Jazwinski, and M. A. Welsch, “Modification of vascular function after handgrip exercise training in 73- to90-yr-old men,” Medicine and Science in Sports and Exercise, vol. 41, no. 7, pp. 1429–1435, 2009. View at Publisher · View at Google Scholar · View at Scopus
  156. C. L. McGowan, A. Visocchi, M. Faulkner et al., “Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives,” European Journal of Applied Physiology, vol. 98, no. 4, pp. 355–362, 2006. View at Publisher · View at Google Scholar
  157. C. L. McGowan, A. S. Levy, P. J. Millar et al., “Acute vascular responses to isometric handgrip exercise and effects of training in persons medicated for hypertension,” American Journal of Physiology, vol. 291, no. 4, pp. H1797–H1802, 2006. View at Publisher · View at Google Scholar · View at Scopus
  158. B. Hornig, V. Maier, and H. Drexler, “Physical training improves endothelial function in patients with chronic heart failure,” Circulation, vol. 93, no. 2, pp. 210–214, 1996. View at Scopus
  159. S. D. Katz, J. Yuen, R. Bijou, and T. H. Lejemtel, “Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure,” Journal of Applied Physiology, vol. 82, no. 5, pp. 1488–1492, 1997. View at Scopus
  160. L. I. Sinoway, J. Shenberger, and J. Wilson, “A 30-day forearm work protocol increases maximal forearm blood flow,” Journal of Applied Physiology, vol. 62, no. 3, pp. 1063–1067, 1987. View at Scopus
  161. M. A. Alomari, M. A. Welsch, R. D. Prisby, C. M. Lee, and R. H. Wood, “Modification of forearm vascular function following short-term handgrip exercise training,” International Journal of Sports Medicine, vol. 22, no. 5, pp. 361–365, 2001. View at Publisher · View at Google Scholar · View at Scopus
  162. A. J. Bank, R. A. Shammas, K. Mullen, and P. P. Chuang, “Effects of short-term forearm exercise training on resistance vessel endothelial function in normal subjects and patients with heart failure,” Journal of Cardiac Failure, vol. 4, no. 3, pp. 193–201, 1998. View at Publisher · View at Google Scholar · View at Scopus
  163. C. L. McGowan, A. S. Levy, N. McCartney, and M. J. MacDonald, “Isometric handgrip training does not improve flow-mediated dilation in subjects with normal blood pressure,” Clinical Science, vol. 112, no. 7-8, pp. 403–409, 2007. View at Publisher · View at Google Scholar · View at Scopus
  164. D. J. Green, N. T. Cable, C. Fox, J. M. Rankin, and R. R. Taylor, “Modification of forearm resistance vessels by exercise training in young men,” Journal of Applied Physiology, vol. 77, no. 4, pp. 1829–1833, 1994. View at Scopus
  165. M. D. Brown, “Exercise and coronary vascular remodelling in the healthy heart,” Experimental Physiology, vol. 88, no. 5, pp. 645–658, 2003. View at Publisher · View at Google Scholar · View at Scopus
  166. B. M. Prior, P. G. Lloyd, H. T. Yang, and R. L. Terjung, “Exercise-induced vascular remodeling,” Exercise and Sport Sciences Reviews, vol. 31, no. 1, pp. 26–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  167. M. D. Delp, R. M. McAllister, and M. H. Laughlin, “Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta,” Journal of Applied Physiology, vol. 75, no. 3, pp. 1354–1363, 1993. View at Scopus
  168. M. D. Delp and M. H. Laughlin, “Time course of enhanced endothelium-mediated dilation in aorta of trained rats,” Medicine and Science in Sports and Exercise, vol. 29, no. 11, pp. 1454–1461, 1997. View at Publisher · View at Google Scholar · View at Scopus
  169. W. C. Sessa, K. Pritchard, N. Seyedi, J. Wang, and T. H. Hintze, “Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression,” Circulation Research, vol. 74, no. 2, pp. 349–353, 1994. View at Scopus
  170. D. Sun, A. Huang, A. Koller, and G. Kaley, “Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats,” Journal of Applied Physiology, vol. 76, no. 5, pp. 2241–2247, 1994. View at Scopus
  171. J. D. Allen, J. P. Geaghan, F. Greenway, and M. A. Welsch, “Time course of improved flow-mediated dilation after short-term exercise training,” Medicine and Science in Sports and Exercise, vol. 35, no. 5, pp. 847–853, 2003. View at Publisher · View at Google Scholar · View at Scopus
  172. T. M. Tinken, D. H. J. Thijssen, M. A. Black, N. T. Cable, and D. J. Green, “Time course of change in vasodilator function and capacity in response to exercise training in humans,” Journal of Physiology, vol. 586, no. 20, pp. 5003–5012, 2008. View at Publisher · View at Google Scholar · View at Scopus
  173. A. P. Burke, A. Farb, G. T. Malcom, Y. H. Liang, J. Smialek, and R. Virmani, “Coronary risk factors and plaque morphology in men with coronary disease who died suddenly,” New England Journal of Medicine, vol. 336, no. 18, pp. 1276–1282, 1997. View at Publisher · View at Google Scholar · View at Scopus
  174. H. Madarame, M. Kurano, H. Takano et al., “Effects of low-intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects,” Clinical Physiology and Functional Imaging, vol. 30, no. 3, pp. 210–213, 2010. View at Scopus
  175. T. Nakajima, H. Takano, M. Kurano et al., “Effects of KAATSU training on haemostasis in healthy subjects,” International Journal of KAATSU Research, vol. 3, no. 1, pp. 11–20, 2007.
  176. T. Herren, P. Bartsch, A. Haeberli, and P. W. Straub, “Increased thrombin-antithrombin III complexes after 1 h of physical exercise,” Journal of Applied Physiology, vol. 73, no. 6, pp. 2499–2504, 1992. View at Scopus
  177. N. H. Wallén, A. H. Goodall, N. Li, and P. Hjemdahl, “Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation,” Clinical Science, vol. 97, no. 1, pp. 27–35, 1999. View at Publisher · View at Google Scholar · View at Scopus
  178. T. Hilberg, E. Eichler, D. Gläser, D. Prasa, J. Stürzebecher, and H. H. W. Gabriel, “Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM,” Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1065–1073, 2003. View at Scopus
  179. T. Hilberg, D. Gläser, C. Reckhart, D. Prasa, J. Stürzebecher, and H. H. W. Gabriel, “Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold,” European Journal of Applied Physiology, vol. 90, no. 5-6, pp. 639–642, 2003. View at Publisher · View at Google Scholar · View at Scopus
  180. T. Nakajima, M. Kurano, H. Iida et al., “Use and safety of KAATSU training: results of a national survey,” International Journal of KAATSU Training Research, vol. 2, no. 1, pp. 5–13, 2006. View at Publisher · View at Google Scholar
  181. Y. Higashi and M. Yoshizumi, “Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients,” Pharmacology and Therapeutics, vol. 102, no. 1, pp. 87–96, 2004. View at Publisher · View at Google Scholar · View at Scopus
  182. D. Shweiki, A. Itin, D. Soffer, and E. Keshet, “Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis,” Nature, vol. 359, no. 6398, pp. 843–845, 1992. View at Publisher · View at Google Scholar · View at Scopus
  183. I. Stein, M. Neeman, D. Shweiki, A. Itin, and E. Keshet, “Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes,” Molecular and Cellular Biology, vol. 15, no. 10, pp. 5363–5368, 1995. View at Scopus
  184. R. S. Richardson, E. A. Noyszewski, K. F. Kendrick, J. S. Leigh, and P. D. Wagner, “Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport,” Journal of Clinical Investigation, vol. 96, no. 4, pp. 1916–1926, 1995. View at Scopus