A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice
Figure 2
CAWS arteritis development and progress in DBA/2 mice. Cardiovascular tissue was sampled every week after CAWS administration, and induced aortitis was observed with an incidence of 100%. The first week panel (a, b—1w) shows slight aortic valve thickening and endocardial inflammation of the Valsalva sinuses; left coronary (LC) sinus, right coronary (RC) sinus, and noncoronary (NC) sinus. The second week panel (a, b—2w) shows expansion of the severe inflammatory lesion around the left coronary arteries (LCA). The third and fourth week panels (a, b—3w and 4w) show the features of the necrosis-related vasculitis. Inflammatory cells have spread to all the layers and sinuses with fibrinoid necrosis in the elastic lamina (arrows). Severe stenosis was found in coronary arteries because of inflammatory cells accumulation.
